Document Type

Article

Journal Title

British journal of cancer

Publication Date

5-20-2008

Volume

98

Abstract

Alterations in epithelial mucin expression are associated with carcinogenesis, but there are few data in biliary tract cancer (BTC). In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker for BTC. We assessed MUC4 and MUC5AC expression in (i) prospectively collected bile and serum specimens from 72 patients with biliary obstruction (39 BTC) by real-time reverse transcriptase-PCR (qPCR) and western blot analysis, and (ii) 79 archived biliary tissues (69 BTC) by immunohistochemistry. In bile, MUC4 protein was detected in 27% of BTC and 29% of primary sclerosing cholangitis (PSC) cases, but not in other benign and malignant biliary diseases (P

MeSH Headings

Adult, Aged, Aged, 80 and over, Bile, Biliary Tract Neoplasms, Blotting, Western, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Middle Aged, Mucin 5AC, Mucin-4, Mucins, Neoplasm Staging, Predictive Value of Tests, Prospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Tumor Markers, Biological

ISSN

1532-1827

Creative Commons License

Creative Commons Attribution-Noncommercial-Share Alike 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

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