British journal of cancer
Alterations in epithelial mucin expression are associated with carcinogenesis, but there are few data in biliary tract cancer (BTC). In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker for BTC. We assessed MUC4 and MUC5AC expression in (i) prospectively collected bile and serum specimens from 72 patients with biliary obstruction (39 BTC) by real-time reverse transcriptase-PCR (qPCR) and western blot analysis, and (ii) 79 archived biliary tissues (69 BTC) by immunohistochemistry. In bile, MUC4 protein was detected in 27% of BTC and 29% of primary sclerosing cholangitis (PSC) cases, but not in other benign and malignant biliary diseases (P
Adult, Aged, Aged, 80 and over, Bile, Biliary Tract Neoplasms, Blotting, Western, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Middle Aged, Mucin 5AC, Mucin-4, Mucins, Neoplasm Staging, Predictive Value of Tests, Prospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Tumor Markers, Biological
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Matull, W. R.; Andreola, F.; Loh, A.; Adiguzel, Z.; Deheragoda, M.; Qureshi, U.; Batra, Surinder K.; Swallow, D. M.; and Pereira, S. P., "MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer." (2008). Journal Articles: Biochemistry & Molecular Biology. 88.