Genes & development
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.
Animals, Base Sequence, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins, DNA Primers, Eye, Female, Kidney, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Mutation, Proteins, Transforming Growth Factor beta
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Dudley, Andrew T.; Lyons, K. M.; and Robertson, E. J., "A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye." (1995). Journal Articles: Genetics, Cell Biology & Anatomy. 7.