Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our objective was to determine the oral bioavailability of CM and the influence of dose on oral absorption. Rats were dosed orally with low dose (10 mg/kg) or high dose (70 mg/kg)
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Alraddadi, Eman A.; Lillico, Ryan; Vennerstrom, Jonathan L.; Lakowski, Ted M.; and Miller, Donald W., "Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth" (2018). Journal Articles: Pharmaceutical Sciences. 21.