Submissions from 2022
Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury., Weimin Tang, Chinmay M. Jogdeo, Sudipta Panja, Siyuan Tang, Ling Ding, Ao Yu, Kirk W. Foster, Del L. Dsouza, Yashpal S. Chhonker, Heather Jensen Smith, Hee-Seong Jang, Erika I. Boesen, Daryl J. Murry, Babu Padanilam, and David Oupicky
Machine Learning Analyses of Highly-Multiplexed Immunofluorescence Identifies Distinct Tumor and Stromal Cell Populations in Primary Pancreatic Tumors, Krysten Vance; Alphan Alitinok; Seth Winfree; Heather Jensen Smith; Benjamin Swanson MD, PhD; Paul M. Grandgenett; Kelsey Klute; Daniel J Crichton; and Michael A. Hollingsworth
Dually Active Polycation/miRNA Nanoparticles for the Treatment of Fibrosis in Alcohol-Associated Liver Disease, Chuhan Zhang, Yu Hang, Weimin Tang, Diptesh Sil, Heather Jensen Smith, Robert G. Bennett, Benita L. McVicker, and David Oupicky
Submissions from 2021
Collagen Fiber Regulation in Human Pediatric Aortic Valve Development and Disease, Cassandra L. Clift, Yan Ru Su, David Bichell, Heather Jensen Smith, Jennifer R. Bethard, Kim Norris-Caneda, Susana Comte-Walters, Lauren E. Ball, Michael A. Hollingsworth, Anand S. Mehta, Richard R. Drake, and Peggi M. Angel
Submissions from 2020
Targeting the Tumor Core: Hypoxia-Responsive Nanoparticles for the Delivery of Chemotherapy to Pancreatic Tumors, Matthew I. Confeld, Babak Mamnoon, Li Feng, Heather Jensen Smith, Priyanka Ray, James Froberg, Jiha Kim, Michael A. Hollingsworth, Mohiuddin Quadir, Yongki Choi, and Sanku Mallik
Submissions from 2019
Human Islet Response to Selected Type 1 Diabetes-Associated Bacteria: A Transcriptome-Based Study, Ahmed M. Abdellatif, Heather Jensen Smith, Robert Z. Harms, and Nora Sarvetnick
Inhibition of Geranylgeranyl Diphosphate Synthase is a Novel Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma, Staci L. Haney, Michelle L. Varney, Yashpal S. Chhonker, Simon Shin, Kamiya Mehla, Ayrianne J. Crawford, Heather Jensen Smith, Lynette M. Smith, Daryl J. Murry, Michael A. Hollingsworth, and Sarah A. Holstein
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas, Meng-Hsiung Hsieh, Joshua H. Choe, Jashkaran Gadhvi, Yoon Jung Kim, Marcus A. Arguez, Madison Palmer, Haleigh Gerold, Chance Nowak, Hung Do, Simbarashe Mazambani, Jordan K. Knighton, Matthew Cha, Justin Goodwin, Min Kyu Kang, Ji Yun Jeong, Shin Yup Lee, Brandon Faubert, Zhenyu Xuan, E. Dale Abel, Claudio Scafoglio, David B. Shackelford, John D. Minna, Pankaj K. Singh, Vladimir Shulaev, Leonidas Bleris, Kenneth Hoyt, James Kim, Masahiro Inoue, Ralph J. DeBerardinis, Tae Hoon Kim, and Jung-Whan Kim
Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy, Richard S. Laschanzky, Lisa E. Humphrey, Jihyun Ma, Lynette M. Smith, Thomas J. Enke, Surendra K. Shukla, Aneesha Dasgupta, Pankaj K. Singh, Gillian M. Howell, Michael G. Brattain, Quan P. Ly, Adrian R. Black, and Jennifer D. Black
Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments, Shengchen Lin, Chongbiao Huang, Venugopal Gunda, Jianwei Sun, Srikumar P. Chellappan, Zengxun Li, Victoria Izumi, Bin Fang, John Koomen, Pankaj K. Singh, Jihui Hao, and Shengyu Yang
The Mitochondrial Deoxyguanosine Kinase is Required for Cancer Cell Stemness in Lung Adenocarcinoma, Shengchen Lin, Chongbiao Huang, Jianwei Sun, Oana Bollt, Xiuchao Wang, Eric Martine, Jiaxin Kang, Matthew D. Taylor, Bin Fang, Pankaj K. Singh, John Koomen, Jihui Hao, and Shengyu Yang
Mitochondrial Superoxide Disrupts the Metabolic and Epigenetic Landscape of CD4, Cassandra M. Moshfegh, Christopher W. Collins, Venugopal Gunda, A. Vasanthakumar, J. Z. Cao, Pankaj K. Singh, L. A. Godley, and Adam J. Case
Metabolic Alterations in Pancreatic Cancer Progression, Enza Vernucci, Jaime Abrego, Venugopal Gunda, Surendra K. Shukla, Aneesha Dasgupta, Vikrant Rai, Nina V. Chaika, Kyla Buettner, Alysha Illies, Fang Yu, Audrey J. Lazenby, Benjamin J. Swanson, and Pankaj K. Singh
Submissions from 2018
Microscale Gene Expression Analysis of Tumor-Associated Macrophages, Kuldeep S. Attri, Kamiya Mehla, Surendra K. Shukla, and Pankaj K. Singh
Aminoglycosides Rapidly Inhibit NAD(P)H Metabolism Increasing Reactive Oxygen Species and Cochlear Cell Demise, Danielle E. Desa, Michael G. Nichols, and Heather Jensen Smith
Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics, Divya Murthy, Kuldeep S. Attri, and Pankaj K. Singh
Met Receptor Inhibitor SU11274 Localizes in the Endoplasmic Reticulum, Edwin J. Wiest, Heather Jensen Smith, and Michael A. Hollingsworth
Submissions from 2017
TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells., Katie L. Bailey, Ekta Agarwal, Sanjib Chowdhury, Jiangtao Luo, Michael G. Brattain, Jennifer D. Black, and J. Wang
MUC1 Facilitates Metabolomic Reprogramming in Triple-Negative Breast Cancer, Gennifer Goode, Venugopal Gunda, Nina V. Chaika, Vinee Purohit, Fang Yu, and Pankaj K. Singh
The Distinct Metabolic Phenotype of Lung Squamous Cell Carcinoma Defines Selective Vulnerability to Glycolytic Inhibition, Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke, Pankaj K. Singh, David B. Shackelford, and Jung-Whan Kim
Genomic Alterations in Mucins Across Cancers, Ryan King, Fang Yu, and Pankaj K. Singh
Submissions from 2016
Validation of Metabolic Alterations in Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (HILIC)-Tandem Mass Spectrometry-Based Metabolomics, Venugopal Gunda, Fang Yu, and Pankaj K. Singh
Thyroid Cancer and Tumor Collaborative Registry (TCCR)., Oleg Shats, Whitney Goldner, Jianmin Feng, Alexander Sherman, Russell B. Smith, and Simon Sherman
Submissions from 2015
Invariant Characteristics of Carcinogenesis., Simon Sherman, Nirosha Rathnayake, and Tengiz Mdzinarishvili
Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth., Surendra K. Shukla, Aneesha Dasgupta, Kamiya Mehla, Venugopal Gunda, Enza Vernucci, Joshua J. Souchek, Gennifer Goode, Ryan King, Anusha Mishra, Ibha Rai, Sangeetha Nagarajan, Nina V. Chaika, Fang Yu, and Surendra K. Shukla
MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism., Surendra K. Shukla, Venugopal Gunda, Jaime Abrego, Dhanya Haridas, Anusha Mishra, Joshua J. Souchek, Nina V. Chaika, Fang Yu, Aaron R. Sasson, A Lazenby, Surinder K. Batra, and Pankaj K. Singh
Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3., Shuping Yang, Lin Zhang, Vinee Purohit, Surendra K. Shukla, Xingcheng Chen, Fang Yu, Kai Fu, Yuanhong Chen, Joyce C. Solheim, Surendra K. Shukla, Wei Song, and Jixin Dong
MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer., Yinbo Zhang, Geoffrey Talmon, and Jing Wang
Gentamicin Differentially Alters Cellular Metabolism of Cochlear Hair Cells as Revealed by NAD(P)H Fluorescence Lifetime Imaging, Lyandysha V. Zholudeva, Kristina G. Ward, Michael G. Nichols, and Heather Jensen Smith
Submissions from 2014
Nerve growth factor regulates neurolymphatic remodeling during corneal inflammation and resolution., Darci M. Fink, Alicia L. Connor, Philip M. Kelley, Maria M. Steele, Michael A. Hollingsworth, and Richard M. Tempero
MUC1 Regulates Cyclin D1 Gene Expression Through p120 Catenin and β-catenin, X. Liu, Thomas C. Caffrey, M. M. Steele, Ashley M. Mohr, Pankaj K. Singh, Prakash Radhakrishnan, David L. Kelly, Y. Wen, and Michael A. Hollingsworth
Web tool for estimating the cancer hazard rates in aging., Tengiz Mdzinarishvili, Alexander Sherman, Oleg Shats, and Simon Sherman
Heuristic modeling of carcinogenesis for the population with dichotomous susceptibility to cancer: a pancreatic cancer example., Tengiz Mdzinarishvili and Simon Sherman
Metabolic Reprogramming Induced by Ketone Bodies Diminishes Pancreatic Cancer Cachexia, Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I. Pipinos, Robert Powers, Fang Yu, and Pankaj K. Singh
Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer., Hongxiu Wen, Yeong C. Kim, Carrie Snyder, Fengxia Xiao, Elizabeth A. Fleissner, Dina Becirovic, Jiangtao Luo, Bradley Downs, Simon Sherman, Kenneth Cowan, Henry T. Lynch, and San Ming Wang
Submissions from 2013
Intra-tumoral heterogeneity in metastatic potential and survival signaling between iso-clonal HCT116 and HCT116b human colon carcinoma cell lines., Sanjib Chowdhury, Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, J. Wang, Michael G. Brattain, and Ashwani Rajput
TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis., Liying Geng, Anathbandhu Chaudhuri, G. Talmon, James L. Wisecarver, and J. Wang
Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi)., Yi Zou, Gillian M. Howell, Lisa E. Humphrey, J. Wang, and Michael G. Brattain
Submissions from 2012
Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma., Nina V. Chaika, Fang Yu, Vinee Purohit, Kamiya Mehla, Audrey J. Lazenby, Dominick J. DiMaio, Judy M. Anderson, Jen Jen Yeh, Keith R. Johnson, Michael A. Hollingsworth, and Pankaj K. Singh
Breast cancer incidence in black and white women stratified by estrogen and progesterone receptor statuses., Michael X. Gleason, Tengiz Mdzinarishvili, and Simon Sherman
Gentamicin Rapidly Inhibits Mitochondrial Metabolism in High-Frequency Cochlear Outer Hair Cells, Heather Jensen Smith, Richard Hallworth, and Michael G. Nichols
A heuristic solution of the identifiability problem of the age-period-cohort analysis of cancer occurrence: lung cancer example., Tengiz Mdzinarishvili and Simon Sherman
Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells., Neka A.K. Simms, Ashwani Rajput, Elizabeth A. Sharratt, Melanie Ongchin, Carol A. Teggart, J. Wang, and Michael G. Brattain
RON - The Con in Colorectal Carcinoma, Shikha Tarang and J. Wang
Submissions from 2011
The Roles of Conserved and Nonconserved Cysteinyl Residues in the Oligomerization and Function of Mammalian Prestin, Benjamin Currall, Danielle Rossino, Heather Jensen Smith, and Richard Hallworth
Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4., Manju George, Mark A. Rainey, Mayumi Naramura, Kirk W. Foster, Melissa S. Holzapfel, Laura L. Willoughby, GuoGuang Ying, Rasna M. Goswami, Channabasavaiah B. Gurumurthy, Vimla Band, Simon C. Satchell, and Hamid Band
MicroRNA-183 Family Expression in Hair Cell Development and Requirement of MicroRNAs for Hair Cell Maintenance and Survival, Michael D. Weston, Marsha L. Pierce, Heather Jensen Smith, Bernd Fritzsch, Sonia Rocha-Sanchez, Kirk W. Beisel, and Garrett A. Soukup
Submissions from 2009
A Generalized Beta model for the age distribution of cancers: application to pancreatic and kidney cancer., Tengiz Mdzinarishvili, Michael X. Gleason, Leo Kinarsky, and Simon Sherman
Submissions from 2008
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons., Eric J. Benner, Rebecca Banerjee, Ashley D. Reynolds, Simon Sherman, Vladimir M. Pisarev, Vladislav Tsiperson, Craig Nemachek, Pawel Ciborowski, Serge Przedborski, R. Lee Mosley, and Howard Gendelman
Submissions from 2007
Long-Distance Three-Color Neuronal Tracing in Fixed Tissue Using NeuroVue Dyes, Heather Jensen Smith, Brian Gray, Katharine Muirhead, Betsy Ohlsson-Wilhelm, and Bernd Fritzsch
Lateral Wall Protein Content Mediates Alterations in Cochlear Outer Hair Cell Mechanics Before and After Hearing Onset, Heather Jensen Smith and Richard Hallworth
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis., J. Wang, Karen Kuropatwinski, Jennie Hauser, Michael R. Rossi, Yunfei Zhou, Alexis Conway, Julie L.C. Kan, Neil W. Gibson, James K.V. Willson, John K. Cowell, and Michael G. Brattain
Submissions from 2004
Molecular Dynamics Simulations of the O-glycosylated 21-residue MUC1 Peptides, A. Rubinstein, L. Kinarsky, and S. Sherman
Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs., Yulei Shen, Javeed Iqbal, Li Xiao, Ryan C. Lynch, Andreas Rosenwald, Louis M. Staudt, Simon Sherman, Karen Dybkaer, Guimei Zhou, James D. Eudy, Jan Delabie, Timothy W. McKeithan, and Wing C. Chan
NMR-based Structural Studies of the Glycosylated MUC1 Tandem Repeat Peptide, G. Suryanarayanan, P. A. Keifer, G. Wang, L. Kinarsky, M. A. Hollingsworth, and S. Sherman
Submissions from 2003
Requirement for the betaI and betaIV tubulin isotypes in mammalian cilia., Heather C Jensen-Smith, Richard F Ludueña, and Richard Hallworth
Cell Type-Specific Reduction of Beta Tubulin Isotypes Synthesized in the Developing Gerbil Organ of Corti, Heather Jensen Smith, Jonquille Eley, Peter S. Steyger, Richard F. Ludueña, and Richard Hallworth
Selective Expression of Beta Tubulin Isotypes in Gerbil Vestibular Sensory Epithelia and Neurons, Brian Perry, Heather Jensen Smith, Richard F. Ludueña, and Richard Hallworth
Submissions from 2002
Role of disulphide bond formation in folding, secretion, and assembly of human chorionic gonadotropin subunits., Elliott Bedows, Ryan J. Darling, Jason A. Wilken, and Simon Sherman
Differential Synthesis of Beta-Tubulin Isotypes in Gerbil Nasal Epithelia, Karen Woo, Heather Jensen Smith, Richard F. Ludueña, and Richard Hallworth