Date of Award

Summer 8-19-2016

Document Type

Thesis

Degree Name

Master of Science (MS)

Programs

Medical Sciences Interdepartmental Area

First Advisor

Corrine Hanson

Second Advisor

Ann Anderson Berry

Third Advisor

Raquel Thomas

Abstract

Background: Postoperative ileus (POI) is the period of intestinal paralysis following any surgical procedure. POI is manifested by nausea, vomiting, abdominal distention, delayed tolerance of oral diet and delayed time to flatus and stool. Little is known about POI following coronary artery bypass grafting (CABG) as no other study has focused specifically on the incidence of POI following CABG.

Purpose: The primary objective of this study is to determine the incidence of POI post CABG. The secondary aim is to evaluate baseline characteristics associated with POI following CABG.

Methods: This was a retrospective cohort study of 100 patients who underwent CABG from October 2014 to February 2015 at Nebraska Medicine. The incidence of POI was the primary outcome. Mann-Whitney U and Chi-square tests were used to compare characteristics between participants who did and did not develop POI. POI risk factors were determined using univariate logistic regression.

Results: The incidence of POI was 15%. BMI and preoperative blood glucose were risk factors for POI (p=0.04 and p=0.03, respectively). Number of days until initiation of oral diet (p=0.014) and number of days until advancement to a solid diet (p=0.003) were also significant.

Conclusion: POI is a significant complication in our population. Although further research is warranted, preoperative nutrition counseling may aid in reducing the incidence of POI by targeting weight loss and insulin sensitivity. Early postoperative oral diet may also be effective for reducing POI following CABG.

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