Document Type

Article

Journal Title

The Journal of experimental medicine

Publication Date

5-5-1997

Volume

185

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.

MeSH Headings

Animals, Encephalomyelitis, Autoimmune, Experimental, Genetic Therapy, Genetic Vectors, Immunization, Passive, Immunotherapy, Interleukin-10, Interleukin-4, Mice, Myelin Basic Protein, Receptors, Antigen, T-Cell, Retroviridae, T-Lymphocytes, Transduction, Genetic

ISSN

0022-1007

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