The Journal of experimental medicine
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.
Animals, Encephalomyelitis, Autoimmune, Experimental, Genetic Therapy, Genetic Vectors, Immunization, Passive, Immunotherapy, Interleukin-10, Interleukin-4, Mice, Myelin Basic Protein, Receptors, Antigen, T-Cell, Retroviridae, T-Lymphocytes, Transduction, Genetic
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Shaw, Michael K.; Lorens, James B.; Dhawan, Archana; DalCanto, Richard; Tse, Harley Y.; Tran, Alyssa B.; Bonpane, Colleen; Eswaran, Shanti L.; Brocke, Stefan; Sarvetnick, Nora; Steinman, Lawrence; Nolan, Garry P.; and Fathman, C. Garrison, "Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis." (1997). Journal Articles: Regenerative Medicine. Paper 2.