The Journal of clinical investigation
Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells. CCR4 was found exclusively on memory CD4(+) T cells during the progression of disease in NOD mice. Cells expressing the CCR4 ligand TARC (thymus- and activation-regulated chemokine) were detected within infiltrated islets from prediabetic mice. Interestingly, neutralization of macrophage-derived chemokine (MDC) with Ab caused a significant reduction of CCR4-positive T cells within the pancreatic infiltrates and inhibited the development of insulitis and diabetes. Furthermore, enhanced recruitment of CCR4-bearing cells in NOD mice resulting from transgenic expression of MDC resulted in acceleration of clinical disease. Cumulatively, the results demonstrate that CCR4-bearing T cells participate in the development of such tissue-driven autoimmune reactions.
Animals, Diabetes Mellitus, Type 1, Immunologic Memory, Immunophenotyping, Islets of Langerhans, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, SCID, Prediabetic State, Receptors, CCR4, Receptors, Chemokine, T-Lymphocytes
Kim, Soon H.; Cleary, Mary M.; Fox, Howard S.; ICOS Coporation; and Sarvetnick, Nora, "CCR4-bearing T cells participate in autoimmune diabetes." (2002). Journal Articles: Regenerative Medicine. Paper 24.