Document Type
Article
Journal Title
Biomolecules
Publication Date
2024
Volume
14
Abstract
Claudins (CLDN1-CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or aberrantly expressed. In the normal colon, CLDN1 and CLDN3-7 are expressed. Although a few claudins, such as CLDN6 and CLDN7, are expressed in CRC their levels are reduced compared to the normal colon. The present review outlines the expression profiles of claudin proteins in CRC and those that are potential biomarkers for prognostication.
MeSH Headings
Humans, Claudin-1, Claudins, Tight Junction Proteins, Colorectal Neoplasms
ISSN
2218-273X
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Cox, Kristin E.; Liu, Shanglei; Hoffman, Robert M.; Batra, Surinder K.; Dhawan, Punita; and Bouvet, Michael, "The Expression of the Claudin Family of Proteins in Colorectal Cancer" (2024). Journal Articles: Biochemistry & Molecular Biology. 171.
https://digitalcommons.unmc.edu/com_bio_articles/171