Document Type
Article
Journal Title
Cancer management and research
Publication Date
Summer 7-31-2013
Volume
5
Abstract
Basal cell carcinoma (BCC) is the most common human malignancy. Recent advances in our understanding of the critical biologic pathways implicated in the development and progression of BCC have led to the development of the first molecular targeted therapy for this disease. The hedgehog pathway is mutated in virtually all patients with BCC and recent trials with vismodegib, an inhibitor of this pathway, have shown significant responses. This review will discuss the importance of the hedgehog pathway in the pathogenesis of BCC and describe in detail the pharmacology of vismodegib in relation to its activity in advanced BCC.
ISSN
1179-1322
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Recommended Citation
Macha, Muzafar A.; Batra, Surinder K.; and Ganti, Apar Kishor, "Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma." (2013). Journal Articles: Biochemistry & Molecular Biology. 54.
https://digitalcommons.unmc.edu/com_bio_articles/54