Document Type
Article
Journal Title
Clinical Proteomics
Publication Date
2019
Volume
16
Abstract
Background: In-depth examination of the plasma proteomic response to infection with a wide variety of pathogens can assist in the development of new diagnostic paradigms, while providing insight into the interdependent pathogenic processes which encompass a host's immunological and physiological responses. Ebola virus (EBOV) causes a highly lethal infection termed Ebola virus disease (EVD) in primates and humans. The Gram negative non-spore forming bacillus
Methods: Herein we report the quantitative proteomic analysis of plasma collected at various times of disease progression from 10 EBOV-infected and 5
Results: A total of 41 plasma proteins displayed significant alterations in abundance during EBOV infection, and 28 proteins had altered levels during
Conclusions: These results advance our understanding of the global plasma proteomic response to EBOV and
DOI Link
ISSN
1542-6416
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Ward, Michael D.; Brueggemann, Ernst E.; Kenny, Tara; Reitstetter, Raven E.; Mahone, Christopher R.; Trevino, Sylvia; Wetzel, Kelly; Donnelly, Ginger C.; Retterer, Cary; Norgren, Robert B.; Panchal, Rekha G.; Warren, Travis K.; Bavari, Sina; and Cazares, Lisa H., "Characterization of the Plasma Proteome of Nonhuman Primates During Ebola Virus Disease or Melioidosis: A Host Response Comparison" (2019). Journal Articles: Genetics, Cell Biology & Anatomy. 34.
https://digitalcommons.unmc.edu/com_gcba_articles/34