18F-Fluorothymidine PET is an Early and Superior Predictor of Progression-Free Survival Following Chemoimmunotherapy of Diffuse Large B Cell Lymphoma: A Multicenter Study
European journal of nuclear medicine and molecular imaging
PURPOSE: To determine whether interim 3'-deoxy-3'-[
METHODS: Ninety-two prospectively enrolled patients with DLBCL underwent both FLT-PET/CT and FDG-PET/CT 18-24 days after two cycles of R-CHOP/R-EPOCH. Deauville-criteria, PERCIST1.0, standardized uptake value (SUV), total lesion glycolysis (TLG), and metabolic tumor volume were used to interpret iFDG-PET/CT while dichotomous visual interpretation was used to interpret iFLT-PET/CT and the results were compared with the 3- and 5-year PFS.
RESULTS: iFLT-PET/CT was negative in 67 (73%) and positive in 25 (27%) patients. iFDG-PET/CT by Deauville criteria was negative (Deauville scores [DS] of 1-3) in 53 (58%) and positive (DS = 4-5) in 39 (42%) patients. Of the 67 iFLT-PET/CT-negative patients, 7 (10.4%) progressed at a median of 14.1 months whereas 14/25 (56.0%) iFLT-PET/CT-positive patients progressed at a median of 7.8 months (P < .0001). Of the 53 Deauville-negative patients, 9 (17.0%) progressed at a median of 14.1 months whereas 12/39 (30.8%) Deauville-positive patients progressed at a median of 5.6 months (P = .11). In multivariate analysis, including iFLT-PET/CT, PERCIST, interim TLG, and interim SUV
CONCLUSIONS: In patients with DLBCL given R-CHOP/R-EPOCH, iFLT-PET/CT is a superior independent predictor of outcome compared with iFDG-PET/CT.
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Minamimoto, Ryogo; Fayad, Luis; Vose, Julie M.; Meza, Jane L.; Advani, Ranjana; Hankins, Jordan; Mottaghy, Felix; Macapinlac, Homer; Heinzel, Alexander; Juweid, Malik E.; and Quon, Andrew, "18F-Fluorothymidine PET is an Early and Superior Predictor of Progression-Free Survival Following Chemoimmunotherapy of Diffuse Large B Cell Lymphoma: A Multicenter Study" (2021). Journal Articles: Oncology and Hematology. 7.