François Lamontagne, Centre de recherche du CHUS de Sherbrooke
Robert A. Fowler, Sunnybrook Health Sciences Centre
Neill K. Adhikari, Sunnybrook Health Sciences Centre
Srinivas Murthy, University of British Columbia
David Brett-Major, University of Nebraska Medical CenterFollow
Michael Jacobs, Royal Free London NHS Foundation Trust
Timothy M. Uyeki, US Centers for Disease Control and Prevention
Constanza Vallenas, World Health Organization
Susan L. Norris, World Health Organization
William A. Fischer, University of North Carolina at Chapel Hill
Thomas E. Fletcher, Liverpool School of Tropical Medicine
Adam C. Levine, International Medical Corps
Paul Reed, Center for Global Health Engagement-Uniformed Services University of the Health Sciences
Daniel G. Bausch, World Health Organization
Sandy Gove, Integrated Management of Adolescent and Adult Illness-Integrated Management of Childhood Illness) Alliance
Andrew Hall, London, UK
Susan Shepherd, Alliance for International Medical Action
Reed A. Siemieniuk, McMaster University
Marie-Claude Lamah, Doctors Without Borders
Rashida Kamara, Ministry of Health and Sanitation
Phiona Nakyeyune, London School of Hygiene & Tropical Medicine
Moses J. Soka, Ministry of Health
Ama Edwin, Korle Bu Teaching Hospital
Afeez A. Hazzan, McMaster University
Shevin T. Jacob, University of Washington
Mubarak Mustafa Elkarsany, Karary University
Takuya Adachi, Toshima Hospital
Lynda Benhadj, Université de Sherbrooke
Christophe Clément, Polyclinique Bordeaux Nord Aquitaine
Ian Crozier, Makerere University
Armando Garcia, Doctors Without Borders
Steven J. Hoffman, McMaster University
Gordon H. Guyatt, McMaster University

Document Type


Journal Title


Publication Date





The 2013-16 Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care, and limitations in the provision of supportive medical care. Case fatality rates in west Africa were initially greater than 70%, but decreased with improvements in supportive care. To inform optimal care in a future outbreak of Ebola virus disease, we employed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to develop evidence-based guidelines for the delivery of supportive care to patients admitted to Ebola treatment units. Key recommendations include administration of oral and, as necessary, intravenous hydration; systematic monitoring of vital signs and volume status; availability of key biochemical testing; adequate staffing ratios; and availability of analgesics, including opioids, for pain relief.



Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Public Domain Dedication 1.0 License.


U.S. Government Work

Included in

Epidemiology Commons