Document Type

Capstone Experience

Graduation Date

5-2025

Degree Name

Master of Public Health

Department

Environmental, Agricultural & Occupational Health

First Committee Member

Eleanor Rogan

Second Committee Member

Muhammad Zahid

Third Committee Member

Ellen Duysen

Abstract

This study examines the association between exposure to the herbicides atrazine and paraquat and the prevalence of Parkinson’s Disease (PD) in various counties of Nebraska. PD is a neurodegenerative disorder that impacts rural agricultural regions in Nebraska, where pesticide application is prevalent. Through a thorough analysis of data sourced from the Nebraska PD Registry, environmental monitoring databases, and pesticide usage, this research aims to establish a correlation between the concentrations of atrazine and paraquat in both groundwater and surface water and the incidence of PD within this region. The study will employ statistical techniques to evaluate this association while accounting for demographic variables, including generalized linear models. Preliminary findings reveal that counties with elevated levels of these pesticides report higher rates of PD. This research addresses a significant gap in the existing literature concerning the specific effects of atrazine and paraquat on risk for PD in Nebraska. The insights derived from this study could inform public health policy and strategies for mitigation. Ultimately, the results may guide the establishment of safer pesticide use guidelines and reinforce protective measures for vulnerable populations, thus contributing to a more comprehensive understanding of the environmental factors that impact neurological health.

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