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Abstract or Description
Asthma, chronic bronchitis and COPD are common adverse respiratory health effects among persons exposed to agriculture organic dust work environments.
- Occupational inhalant exposures have been increasingly associated with the risk of rheumatoid arthritis (RA) disease development, particularly among males. Agriculture workers have increased risk of RA and generalized bone disease.
- Chronic lung disease is associated with production of characteristic autoantibodies associated with RA (e.g.anti-citrullinated antibodies), even in absence of RA disease.
- The mechanistic link between pulmonary inflammation and arthritis (and vice versa) remains poorly understood. Animal models are lacking.
Rentfro, Kathryn; Thiele, Geoffrey M.; Janike, Katherine; Nelson, Amy J.; Duryee, Michael J.; England, Bryant R.; Romberger, Debra J.; Carrington, Joseph; Wang, Dong; Swanson, Benjamin J.; Klassen, Lynell W.; Mikuls, Ted R.; and Poole, Jill A., "The Induction of Autoimmune Arthritis and Sex differences in Mice Impact the Lung Inflammatory Response to Repetitive Inhalant Organic Dust Extract Exposures" (2021). EMET Projects. 5.