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Presentation date

Summer 8-12-2021

College, Institute, or Department

MD-PhD Scholars Program

Faculty Mentor

Dr. Jason MacTaggart

Research Mentor

Dr. Jason MacTaggart, Dr. Alexey Kamenskiy

Abstract

Peripheral Artery Disease (PAD) is the chronic obstruction of blood flow to the extremities caused by plaque buildup. Poor circulation results in exertional pain, numbness, and weakness, and in severe cases, can manifest critical conditions, including gangrene and limb loss. PAD affects approximately 8.5 million Americans and costs the United States $21 billion annually in direct medical expenses. High expenditures are attributed to operation and intervention failures resulting in frequent need for revascularization. Treatment of PAD typically involves lifestyle/diet adjustments, bypass surgery, or angioplasty/stenting. Unfortunately, repeated limb deformation during locomotion often results in adverse repair device-artery interactions, which hinder the long-term efficacy of endovascular therapies. Patient and lesion-specific device selection guided by computational modeling can help improve clinical outcomes, but these models rely heavily on accurately recorded three-dimensional arterial geometry and plaque composition. Intravascular ultrasound (IVUS) is a minimally invasive method of endovascular imaging that allows evaluation of the geometry and composition of the arterial wall, but its two-dimensional nature is often insufficient to capture complex three-dimensional plaques. We have developed a method of obtaining three-dimensional arterial geometry from two-dimensional IVUS images to build Computer-Aided Design models of calcified human femoropopliteal arteries. Our imaging method will allow for the characterization of calcium, necrotic core, fibrofatty, and fibrous tissue using IVUS. Correlation of IVUS images with conventional histology, micro-CT imaging, and clinical CTA data will help inform computational models.

Keywords

Peripheral Artery Disease, Intravascular Ultrasound, Femoropopliteal Artery, Arterial Plaque, Endovascular Therapy

Non-Destructive Characterization of Peripheral Arteries using Intravascular Ultrasound

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