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Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food disease characterized by delayed vomiting and diarrhea, often at the first ingestion of the food. The clinical phenotype of FPIES, including trigger food and disease course, varies by region. A literature review of the most common FPIES foods in children in the United States and worldwide includes cow’s milk, soy, oats, rice, and egg.
We sought to survey the most common FPIES foods seen at Children’s hospital in the past five years.
A data search of the EPIC electronic medical record using FPIES codes ICD-10 (K52.21) and ICD-9 (558.3) as the primary diagnosis revealed 40 cases and 23 foods.
The five most common foods seen in FPIES cases presenting at Children’s Hospital are oat, rice, sweet potato, milk and egg. Fish was much more common in our cohort than in the previously studied populations.
We also report the most recently diagnosed FPIES cases at Children’s hospital. One case with two less common food triggers, and a case of FPIES with concomitant IgE positivity to the food (atypical FPIES).
Nelson, Rachel and Hopp, Russell, "Food Protein Induced Enterocolitis Syndrome Triggers at Children’s Hospital" (2021). Child Health Research Institute Pediatric Research Forum. 20.