Document Type
Article
Journal Title
ADMET & DMPK
Publication Date
2022
Volume
10
Abstract
Antimicrobial peptide research remains active not only because of the growing antibiotic resistance problem but also our desire to understand the role of innate immune peptides in host defense. While numerous peptides are currently under active development for topical use, this article highlights peptides with systemic efficacy. The scaffolds of these peptides range from linear to cyclic forms. The neutropenic mouse model is well established to illustrate antimicrobial efficacy from direct killing. The majority of tests, however, are conducted using normal mice so that both direct antimicrobial and immune regulatory effects can be characterized. These systemic examples underscore the possibility of adding new candidates to the list of the existing peptide antibiotics to more effectively combat antibiotic-resistant bacteria, fungi, and parasites.
DOI Link
ISSN
1848-7718
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Wang, Guangshun and Mechesso, Abraham F., "Realistic and Critical Review of the State of Systemic Anti-Microbial Peptides" (2022). Journal Articles: Pathology and Microbiology. 83.
https://digitalcommons.unmc.edu/com_pathmicro_articles/83