Document Type


Journal Title

Clinical chemistry and laboratory medicine : CCLM / FESCC

Publication Date





BACKGROUND: The routine use of brain natriuretic peptide (BNP) in pediatric cardiac surgery remains controversial. Our aim was to test whether BNP adds information to predict risk in pediatric cardiac surgery.

METHODS: In all, 587 children undergoing cardiac surgery (median age 6.3 months; 1.2-35.9 months) were prospectively enrolled at a single institution. BNP was measured pre-operatively, on every post-operative day in the intensive care unit, and before discharge. The primary outcome was major complications and length ventilator stay >15 days. A first risk prediction model was fitted using Cox proportional hazards model with age, body surface area and Aristotle score as continuous predictors. A second model was built adding cardiopulmonary bypass time and arterial lactate at the end of operation to the first model. Then, peak post-operative log-BNP was added to both models. Analysis to test discrimination, calibration, and reclassification were performed.

RESULTS: BNP increased after surgery (p

CONCLUSIONS: Our data indicates that BNP may improve the risk prediction in pediatric cardiac surgery, supporting its routine use in this setting.

MeSH Headings

Adolescent, Adult, Child, Child, Preschool, Female, Heart Defects, Congenital, Humans, Infant, Intensive Care Units, Male, Natriuretic Peptide, Brain, Predictive Value of Tests, Prognosis, Risk Factors, Young Adult




Clinical Chemistry and Laboratory Medicine (CCLM). Volume 53, Issue 11, Pages 1839–1846, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2014-1084, April 2015

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Pediatrics Commons