Document Type
Article
Journal Title
The Open Colorectal Carcinoma
Publication Date
Spring 4-27-2012
Volume
5
Abstract
The recepteur d’origine nantais (RON) is a member of MET family of receptor tyrosine kinase (RTKs), an overexpression of which has been observed in several cancers. The expression of RON gene is required during embryonic development and also plays critical roles in regulating macrophage inflammatory response. In CRC, the overexpression of moderate RON activity contributes to their oncogenic potential by regulating several key processes such as proliferation, motility and resistance to apoptosis. Interestingly, an aberrant RON expression is often associated with the generation of several splice variants with unique transforming activities. The targeting of RON signaling pathway by the use of mono-clonal antibodies and small-molecule inhibitors has shown promising therapeutic results in animal models. The present ar-ticle aims at summarizing the current understanding of RON kinase in CRC.
DOI Link
ISSN
1876-8202
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Tarang, Shikha and Wang, J., "RON - The Con in Colorectal Carcinoma" (2012). Journal Articles: Eppley Institute. 13.
https://digitalcommons.unmc.edu/eppley_articles/13