Immune Cell Expression Signatures in B cell Lymphoma
Download Ramiah Caine Original Presentation File (1.6 MB)
College, Institute, or Department
Eppley Institute for Research in Cancer
Intro: B-cell lymphomas are a group of diseases that originate from the B cell compartment of your white blood cells. B-cell lymphoma and High-Grade Lymphoma are difficult to distinguish by pathologists based on morphology but have been shown to have very different expression profiles by suggesting these lymphomas come from different stages of B-cell development. M&M: xCell is an analytical tool to impute gene expression profiles and provide an estimation of the abundances of member cell types in a mixed cell population, using gene expression data. Results: A program called xCell was utilized to see that High-Grade Lymphoma cases were enhanced for memory B-cell marks while Burkitt Lymphoma cases were improved for plasma cell signatures suggesting a potential difference in the normal cell counterpart. For immune-cell signatures in the microenvironment, I observed that High Grade Lymphoma samples had a statistically significant increase in T-regulatory cell signatures Conclusions: I observed that High Grade Lymphoma samples had a statistically significant increase in T-regulatory cell signatures while Burkitt Lymphoma samples had a statistically significant increase in T-helper 1 signatures. Taken together, these results suggest differential microenvironments in these malignancies which could be exploited in therapeutic strategies as T-regulatory and T-helper 1 subsets can influence anti-tumor responses.
lymphoma, B-cell, Immune Cell
Caine, Ramiah; Herek, Tyler; and Iqbal, Javeed, "Immune Cell Expression Signatures in B cell Lymphoma" (2020). Posters: 2020 Summer Undergraduate Research Program. 26.