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Presentation date

Summer 8-10-2022

College, Institute, or Department

Internal Medicine

Faculty Mentor

Toni Goeser

Research Mentor

Dr. Krishna Gundabolu


CVST is a rare location of thrombosis involving Dural/ cerebral venous sinuses. It affects around 5-10 people per million population annually.

It is an uncommon but life-threatening form of stroke affecting younger individuals. Therefore, identifying and treating in a timely manner is critical.

Rarer thrombotic disorders like paroxysmal nocturnal hemoglobinuria (PNH) or Janus Kinase 2 (JAK2) mutation positive myeloproliferative neoplasms (MPN) can rarely present with CVST. It can also present during pregnancy for the first time.

Diagnosis is often established by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI).

Infections, certain medication use (asparaginase or birth control pills) could lead to CVST. Patients often present with headaches, seizures or neurological deficits.

Management is often with systemic anticoagulation despite intraparenchymal hemorrhage. Reducing intracranial pressure by invasive approaches is sometimes needed.


Cerebral Venous Sinus Thrombosis, CVST, Thrombosis, VITT, COVID-19, Stroke, Thrombotic Disorder, Anticoagulation, Antithrombotic Therapy, Dural Venous Sinus, Oral Contraceptive, Mutation, Retrospective Study, Thrombophilia

Cerebral Venous Sinus Thrombosis (CVST): Long-Term Single-Center Experience