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Background: Alcohol-associated liver disease (ALD) encompasses the liver manifestation of chronic alcohol abuse, characterized by different stages of liver damage that progresses from fat accumulation to steatohepatitis, fibrosis and eventually cirrhosis. The severity of liver damage is influenced by age, which is also a predictor for ALD-related mortality. Thus, the purpose of this study was to investigate how aging and alcohol affect lipid metabolism in the liver. Methods: Rats aged 4 months, 8 months, 12 months, and 22 months-old were pair-fed Lieber-DeCarli control or ethanol diet for 6 weeks. Serum and liver were collected for analyses when rats were euthanized. Analyses included histopathology, measurements of non-esterified fatty acid content and hepatic triglyceride content, and gene expression.
aging, alcohol, liver disease, fatty acids
Yoon, Jessica S.; Mahalingam, Sundararajan; Kubik, Jacy L.; Bellamkonda, Ramesh; Casey, Carol A.; Kharbanda, Kusum K.; and Rasineni, Karuna, "The Effects of Age and Alcohol on Lipid Metabolism in the Liver" (2022). Posters: 2022 Summer Undergraduate Research Program. 33.