Document Type

Article

Journal Title

British journal of cancer

Publication Date

2-9-2004

Volume

90

Abstract

MUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines, but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we investigated the aberrant regulation of MUC4 expression in vivo using clonal human pancreatic tumour cells (CD18/HPAF) grown either orthotopically in the pancreas (OT) or ectopically in subcutaneous tissue (SC) in the nude mice. Histological examination of the OT and SC tumours showed moderately differentiated and anaplastic morphology, respectively. The OT tumour cells showed metastases to distant lymph nodes and faster tumour growth (P

MeSH Headings

Animals, Blotting, Northern, Choristoma, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Immunosuppressive Agents, Mice, Mice, Nude, Mucin-4, Mucins, Pancreatic Neoplasms, Transforming Growth Factor beta, Transforming Growth Factor beta2, Transplantation, Heterologous, Tumor Cells, Cultured, Tumor Markers, Biological

ISSN

0007-0920

Creative Commons License

Creative Commons Attribution-Noncommercial-Share Alike 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

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