Document Type
Article
Journal Title
British journal of cancer
Publication Date
11-1-2004
Volume
91
Abstract
Mucins are members of an expanding family of large multifunctional glycoproteins. Pancreatic mucins have important biological functions, including the protection, lubrication, and moisturisation of the surfaces of epithelial tissues lining ductal structures within the pancreas. Several lines of evidence support the notion that deregulated mucin production is a hallmark of inflammatory and neoplastic disorders of the pancreas. Herein, we discuss the factors that contribute to the lethality of pancreatic cancer as well as the key role played by mucins, particularly MUC1 and MUC4, in the development and progression of the disease. Aspects pertaining to the aberrant expression and glycosylation of mucins are discussed, with special emphasis on their potential impact on the design and implementation of adequate diagnostic and therapeutic strategies for combating this lethal malignancy.
MeSH Headings
Glycosylation, Humans, Mucin-1, Mucin-4, Mucins, Pancreatic Neoplasms
ISSN
0007-0920
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.
Recommended Citation
Moniaux, N.; Andrianifahanana, M.; Brand, R. E.; and Batra, Surinder K., "Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy." (2004). Journal Articles: Biochemistry & Molecular Biology. 96.
https://digitalcommons.unmc.edu/com_bio_articles/96