Date of Award
Doctor of Philosophy (PhD)
Pharmacology and Experimental Neuroscience
Pharmacokinetics and pharmacodynamics studies are required for bench to bedside translation of any new drug, formulation or device. Multifunctional magnetite nanocarriers enable magnetic resonance imaging tracking of nanomaterial encased antiretroviral drugs serving to improve the effectiveness of formulation developments. Targeting ligands used to deliver nanoparticles to HIV harboring cells can be tested using multifunctional magnetite nanocarriers. To this end, two types of magnetite nanocarriers were developed. These included small magnetite antiretroviral therapy particles. The second were ALN-PEG coated magnetite particles for testing macrophages targeting ligands. Overall, these works should serve to speed the development of long acting nanoformulated ART to improve access and effectiveness of treatment regimens for the infected human host.
Li, Tianyuzi, "Targeted Magnetite Tissue Delivery for Antiretroviral Pharmacokinetics" (2015). Theses & Dissertations. 8.
Figure 2 premission (paper).pdf (148 kB)
Figure 2 premission (email).pdf (124 kB)
Figure 2 premission.pdf (137 kB)
Figure 3 premission.pdf (121 kB)
Figure 4 premission.pdf (113 kB)
Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy premission.pdf (136 kB)
Small magnetite antiretroviral therapeutic nanoparticle probes for MRI of drug biodistribution premission.pdf (47 kB)