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Theses/Dissertations from 2025

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Targeting SGPP1 in Pancreatic Cancer: Valproic Acid as a Potential Therapeutic via HDAC Inhibition and S1P Pathway Modulation, Hamed Abbasi

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Advancing Drug Development through Translational DMPK and Model-Informed Pharmacokinetic Approaches, Nusrat Ahmed

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Beyond the Bruise: Understanding Injury Risk Factors Among Livestock Workers in Cattle Feedyards and Animal Handling Farms and Ranches, Rishad Ahmed

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Relationship Between Maternal Plasma Retinol and Provitamin A Carotenoids with Fetal and Infant Kidney Development, Anum Akbar

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Colostrum Extracellular Vesicle are Neuroprotective in the MPTP Intoxicated Mouse Model of Parkinson's Disease, Samia Akter

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From Vector to Consequence: Integrating Vector Surveillance, Environmental Drivers, and Public Health Impact into Lyme Disease Risk Management, Kathleen E. Angell

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Navigating the Divide: COVID-19 Vaccine Access, Uptake, and Persistent Vaccine Refusal in Nebraska, Julia Bai

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Posterior Anatomic Limit for Mandibular Molar Distalization in Subjects with Different Growth Patterns, Genders, and Growth Status, Rehana Bashir

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Functional Importance of Pax5 and NrCAM in Highly Aggressive AR-Independent Prostate Cancer, Sreyashi Bhattacharya

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A Novel Approach for Understanding the Role of Bone Remodeling in Early Structural Knee Osteoarthritis, Reece Blay

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Mechanistic Insight of Neuropilin-2 Expression during the Progression of Prostate Cancer, Sanika Bodas

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Development and Evaluation of the Cystiene Cathepsin Trapping Approach Incorporated in NTSR1- and FAP-Targeted Radiotherapeutics, Katherine Brake

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Immunosuppression and Epigenetic Therapy: Amyloid Precursor-Like Protein 2-Mediated Macrophage Dynamics and Histone Deacetylase Inhibition in Neuroblastoma, Gabrielle L. Brumfield

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Neuroplasticity in Motion: Exploring Neural Oscillatory Activity and Physical Therapy Interventions in Adolescents and Adults with Cerebral Palsy, Morgan T. Busboom-Matulka

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Investigating the Effects of Transcription Factor Binding and Genetic Variants in the Striatum of Post-Mortem Cohorts with Opioid Use Disorder, Rajashree Chakraborty

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Evaluating Current Practices in Operative Nontechnical Skills Training and Feedback in General Surgery Residency: A Mixed Methods Approach, Madeline Cloonan

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Coordinating Connections: A Mixed-Methods Exploration of Relational Coordination and Interprofessional Team Development with Health Professions Students and Survivors of Stroke, Teresa Marie Cochran

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Evaluating Clinical Competency in Undergraduate Nursing Students: A Mixed Methods Study, Emily C. Coffey

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Prebiotics to Augment the Gut Microbiome for Patients with Lymphoma or Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation: The Primal Trial, Christopher R. D'Angelo

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Variable Selection and Prediction Using Machine Learning Models in High-Dimensional Data, Apu Chandra Das

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The Splicing Factor PTBP1 Interacts with RUNX1 and is Required for Leukemia Cell Survival, Arjun Dhir

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The Design, Synthesis and Biological Evaluation of Novel 17β-Hydroxysteroid Dehydrogenase Modulators, Louise F. Dow

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BET Protein Inhibition Relieves Myeloid-Derived Suppressor Cell-mediated Immune Suppression in Chronic Lymphocytic Leukemia, Erin M. Drengler

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Neurodegenerative Disease Mechanisms: Mitochondrial Impairment, Tau Aggregation, and Neuroinflammation as Central Drivers of Disease Progression, Luis D. Estrella

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Exposures, Protections, and Barriers: Advancing Understanding of Agricultural Worker Health, Alexandra A. Farfalla

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Understanding Stakeholder Perspectives, Medical Student Metacognition and Reflections on Learning Order Entry in the Electronic Health Record, Abbey L. Fingeret

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Schistosoma haematobium Infection in Ethiopian Children: Evaluating Praziquantel Efficacy, Nutritional Effects, and Diagnosis Using FlukeCatcher, Louis Fok

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Multi-Modal MRI for the Pre-Clinical Evaluation of HIV-Linked Changes in the Central Nervous System, Gabriel Gauthier

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A Comparison of Resurgence Following DRA and DRO, Alysa Georgopoulos

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Navigating Nutrition Between Cultures: A Mixed Methods Study of Dietary Acculturation and Generational Status in Mexican-American Populations, Roger Gonzales

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A Comparison of Tenecteplase to Alteplase for Treatment of Acute Ischemic Stroke Using Epic Cosmos Database, Marco Gonzalez Castellon

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Role of Stabilin-1 Expressing Macrophages in Colorectal Liver Metastasis, Jampa L. Gurung

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Targeting Oxidative and Nitrosative Stress: The Role of Omega-3 Derived RvD2 and NRF2 Signaling in Hypertensive-Affected Placenta, Taija Hahka

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Investigate the Role of TGFβ3 in Regulating IRF6 and ΔNp63 in Periderm Desquamation, Nam Ha

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Integrating Artificial Intelligence and Machine Learning with Causal Inference for Early Detection & Management of Cardiac Rejection, Roman G. Haynatzki

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The Effects of Arbitrary Reinforcers on DRO Efficiency, Reinstatement, and Reacquisition, Zeinab Hedroj

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Temporal Patterns of Ectopic Pregnancy: Using the Electronic Health Record to Illuminate a Dark Corner in Women's Health, Kirsten Hepburn

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An Extension of a Break-to-Choice Intervention with Isolated Contingency Tests for Children with Multiply Maintained Challenging Behavior, McKenna E. Herbek

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Microbiome Compositional State and Its Relation to Gut Dysbiosis in the Common Marmoset, Jordan B. Hernandez

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Presence and Performance: A Cross-Campus Analysis of Academic Performance and Course Evaluations Through the Lens of the Community of Inquiry, Shaun Horak

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Kinase Suppressor of Ras 2 Regulates Energy Balance and Tumor Initiation, Dianna H. Huisman

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Navigating Lipid Nanoparticle Design: From Microfluidic Optimization for RNA Delivery in Pancreatic Cancer to Extended-release Formulations for HIV-1 Therapy., Farhana Islam

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Optimal Two-Stage Phase II Bayesian Design, Yuanyuan Ji

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Impact of Mesenchymal Stem Cell-Derived Chemokines and Other Tumor Microenvironment Factors in Bone-Metastatic Prostate Cancer, Catherine S. Johnson

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Formative Research Study: Investigating the African American Community Perspective of Prostate Cancer by Triangulating the Association of Marital Status Within a Prostate Cancer Staging From a Population Approach, George Johnson

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Heart Failure in Rheumatoid Arthritis: Epidemiology, Determinants, and Gaps in Risk Stratification, Tate M. Johnson

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Restoring Translational Control with Novel Small Molecule Activators of PP2A in Cancer Cells, Kayla A. Jonas

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Leveraging Biomarkers to Accelerate Drug Development and Patient Care, Vineet A. Joshi

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Development of Self-Assembled Polymeric Polyplexes for MicroRNA Delivery: Toward Treatment of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

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Neoadjuvant Gene Therapy with Calreticulin and R848: A Novel Approach to Pancreatic Ductal Adenocarcinoma Treatment, Ekta Kapoor

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Targeting FOXM1/Aurora Kinase B Axis Attenuates Small Cell Lung Cancer Growth, Metastasis and Chemoresistance, Md Arafat Khan

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Intrinsic and Extrinsic Drivers of Bioaerosol Decay: Investigating Pathogen Stability of Bacteriophage MS2, Sin Nombre Virus, and SARS-COV-2 in Simulated Environments, Elizabeth A. Klug

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Model Informed Approach to Support the Repurposing of Brompheniramine for Tumor Associated Neuroinflammation: Mechanistic Dose Prediction and Brain Exposure Assessment, Amit C. Kolhe

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Assessment of Cellular Metabolism in Disease Progression and Prevention, Sai Sundeep Kollala

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Biological Response of Abaloparatide and Alendronate on the Osteochondral Tissue of TMJ-OA, Jonjei Ku

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Elucidating the Mechanism of the Polymeric Drug PAMD-CH17’S Novel Anti-Leukemic Effects, Calvin Lam

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Targeting TREM1: A Novel Therapeutic Approach to Mitigate Necrotizing Enterocolitis Injury in Murine Neonates, Zainab Damilola Lawal

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The Impact of Teaching Multiple Responses on Resurgence of Target Behavior and Persistence of Alternative Responding, Brittany H. Loder-Lafferty

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Peripheral Blood Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease, Brent A. Luedders

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Drivers and Mechanisms of Golgi Fragmentation as a Modulator of Disease, Amanda Macke

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Design and Synthesis of FDI-6-Based Hydrophobic Tag Degraders Targeting FOXM1, Callie J. Martin

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Climate Change and Infectious Disease Dynamics in the U.S.: Spatial-Temporal Patterns and Epidemiological Insights, Raheleh Mohammadi

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Evaluating the Therapeutic Potential of Geranylgeranyl Diphosphate Synthase Inhibitor, RAM2061, in Myeloma Bone Disease, Molly Muehlebach

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Demystifying Tumor-Mediated Local and Systemic Immunosuppression in Pancreatic Ductal Adenocarcinoma, Clara Mundry

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The Role of Cell Size and Proliferation in Intestinal Crypt Organization, Rosemary M. Mwithiga

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Evaluating BMX-001 as a Selective Radioprotector for Healthy Tissue in Pelvic Cancers, Molly Myers

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Symptom Clusters and their Association with Health-Related Quality of Life in Pediatric Cancer Survivors After Treatment Completion, Krishtee Napit

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Causal Mediation Analysis with Joint Modeling Framework for Recurrent Events Mediator and Survival Outcomes, Fang Niu

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Molecular Mechanisms of Aberrant Metabolism in Pancreatic Cancer Aggressiveness and Metastasis, Ayoola Ogunleye

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Cholestasis and Fluid Flow are Biomechanic Regulators of Cholangiocarcinoma Progression, Andrew Oleksijew

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Effects of Treatment Integrity Level and Error Type on Dro Efficacy: A Parametric and Comparative Analysis, Paige O'Neill

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Combinatorial Antiviral Regimen as Strategy to Control SARS-CoV-2 Infections, Kabita Pandey

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Novel Drug Delivery Platforms for Small Molecule and miRNA-Based Therapies in Acute Myeloid Leukemia, Qiaoyu Pan

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Optimizing Geranylgeranyl Diphosphate Synthase Inhibitor (GGSI) Therapy for Multiple Myeloma, Ashruti Pant

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Study of Peptide Amphiphiles as Antimicrobial Agents, Aramis J. Pereira

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Eating the Fat of the Land: The Work of Coxiella burnetii To Traverse Intracellular Lipid Landscapes, Charlie Porto

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Claudin-1-Mediated Signaling and Therapy Resistance in Colorectal Cancer: From Mechanism to Translation, Mark W. Primeaux

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Dissecting MUC16 in Pancreatic Cancer: Imaging Targetability, Oncogenic Signaling and Immune Suppression, Christabelle Rajesh

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Decoding IPMN: Exploring the Molecular Bridges of Pancreatic Cancer Progression, Pratima Raut

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Disrupted Rhythms: The Impact of Altered Neural Oscillations and Sleep Patterns on Cognitive Impairment and Amyloid Accumulation in Alzheimer’s Disease, Maggie Rempe

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Investigating the Role of Androgen Deprivation on AXL Regulation in Prostate Cancer, Amanda Robotham

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Apolipoprotein E4, Tauopathy, and Brain Injury: Molecular Insights into Alzheimer's Disease Pathology, Nashanthea J. Roland

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Validating the Ability of IAG933 to Block the Interaction of YAP1 and TEAD in Ovarian Cancer Cells, Alex Sage

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Targeting Metabolic and Heme Degradation Pathways in Prostate Cancer: A New Therapeutic Strategy, Dania Sahtout

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Cross-Cultural Care in Perinatal Nursing, Erin Salahshurian

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Cardiovascular Disease Risk, Risk Factors, and Healthcare Utilization Among Latino Male Migrant Farmworkers in Nebraska, Maria Jose Sanchez Roman

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Analyzing Food Access: An Investigation of Food Insecurity amongst Latinos in Rural Nebraska, Natalia Santos

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Characterization and Identification of Staphylococcus Aureus Pyruvate Transporters, Cleofes Sarmiento

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Multilineage Hematopoietic Function of SAM-Containing Proteins, Meg Schaefer

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Staphylococcus aureus Encodes Multiple Arginine Transporters, Gabrielle Schulze

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Identification and Preclinical Assessment of Novel Therapeutic Modalities in Environmental Exposure-induced Lung Disease, Aaron D. Schwab

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Targeting Human Bromodomain Proteins for the Treatment of Medulloblastoma, Zalak Sheth

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Evaluation of the Gut Microbiome in Chronic Lymphocytic Leukemia: Disease Insights and Potential Therapeutic Avenues, Sydney Skupa

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Coxiella burnetii Manipulation of Membrane Contact Sites in the Intracellular Niche, Margaret F. Sladek

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Multimodal Longitudinal Assessment of the Developmental Trajectory of Resting State Connectivity and Neural Oscillatory Dynamics Supporting Executive Function, Jake Son

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A Replication and Extension of the Enhanced Choice Model for Children Who Exhibit Challenging Behavior, Jessica Tran

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The Characterization of Per- and Polyfluoroalkyl Substances (PFAS) in Nebraska Drinking Water and Human Health Impacts, Sarah Tucker

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Mucin-type O-glycans Protects Against Pancreatitis, Khadija Turabi

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Behavior Analysts’ Training and Practices Regarding Cultural Diversity: A Replication and Extension, Tania M. Valdez-Nuguid

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Immunoplasticity: A Key Determinant in the Outcome of Neurosurgical Biofilm Infection, Zachary A. Van Roy