Document Type
Article
Journal Title
Molecular cancer
Publication Date
3-19-2021
Volume
20
Abstract
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading cause of death worldwide. Despite recent advances in therapies, the overall 5-year survival rate of LC remains less than 20%. The efficacy of current therapeutic approaches is compromised by inherent or acquired drug-resistance and severe off-target effects. Therefore, the identification and development of innovative and effective therapeutic approaches are critically desired for LC. The development of RNA-mediated gene inhibition technologies was a turning point in the field of RNA biology. The critical regulatory role of different RNAs in multiple cancer pathways makes them a rich source of targets and innovative tools for developing anticancer therapies. The identification of antisense sequences, short interfering RNAs (siRNAs), microRNAs (miRNAs or miRs), anti-miRs, and mRNA-based platforms holds great promise in preclinical and early clinical evaluation against LC. In the last decade, RNA-based therapies have substantially expanded and tested in clinical trials for multiple malignancies, including LC. This article describes the current understanding of various aspects of RNA-based therapeutics, including modern platforms, modifications, and combinations with chemo-/immunotherapies that have translational potential for LC therapies.
ISSN
1476-4598
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Khan, Parvez; Siddiqui, Jawed A.; Lakshmanan, Imayavaramban; Ganti, Apar Kishor; Salgia, Ravi; Jain, Maneesh; Batra, Surinder K.; and Nasser, Mohd W., "RNA-Based Therapies: A Cog in the Wheel of Lung Cancer Defense" (2021). Journal Articles: Biochemistry & Molecular Biology. 137.
https://digitalcommons.unmc.edu/com_bio_articles/137