Document Type
Article
Journal Title
The FASEB Journal
Publication Date
2023
Volume
37
Abstract
G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of "most targeted receptors". About one-third of the commercially available drugs for various diseases target the GPCRs. Fibroblasts lay the architectural skeleton of the body, and play a key role in supporting the growth, maintenance, and repair of almost all tissues by responding to the cellular cues via diverse and intricate GPCR signaling pathways. This review discusses the dynamic architecture of the GPCRs and their intertwined signaling in pathological conditions such as idiopathic pulmonary fibrosis, cardiac fibrosis, pancreatic fibrosis, hepatic fibrosis, and cancer as opposed to the GPCR signaling of fibroblasts in physiological conditions. Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast-mediated diseases. This review highlights the importance of designing and adaptation of next-generation strategies such as GPCR-omics, focused target identification, polypharmacology, and effective personalized medicine approaches to achieve better therapeutic outcomes for fibrosis and fibrosis associated malignancies.
MeSH Headings
Humans, Receptors, G-Protein-Coupled, Signal Transduction, Fibroblasts, Neoplasms, Fibrosis
ISSN
1530-6860
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Dwivedi, Nidhi V.; Datta, Souvik; El-Kersh, Karim; Sadikot, Ruxana MD, MRCP; Ganti, Apar Kishor; Batra, Surinder K.; and Jain, Maneesh, "GPCRs and Fibroblast Heterogeneity in Fibroblast-Associated Diseases" (2023). Journal Articles: Biochemistry & Molecular Biology. 164.
https://digitalcommons.unmc.edu/com_bio_articles/164