Document Type
Article
Journal Title
Biomed Research International
Publication Date
Fall 10-1-2015
Volume
2015
Abstract
Chronic heart failure (CHF) is a global health problem affecting millions of people. Autonomic dysfunction and disordered breathing patterns are commonly observed in patients with CHF, and both are strongly related to poor prognosis and high mortality risk. Tonic activation of carotid body (CB) chemoreceptors contributes to sympathoexcitation and disordered breathing patterns in experimental models of CHF. Recent studies show that ablation of the CB chemoreceptors improves autonomic function and breathing control in CHF and improves survival. These exciting findings indicate that alterations in CB function are critical to the progression of CHF. Therefore, better understanding of the physiology of the CB chemoreflex in CHF could lead to improvements in current treatments and clinical management of patients with CHF characterized by high chemosensitivity. Accordingly, the main focus of this brief review is to summarize current knowledge of CB chemoreflex function in different experimental models of CHF and to comment on their potential translation to treatment of human CHF.
DOI Link
ISSN
2314-6141
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Andrade, David C.; Lucero, Claudia; Toledo, Camilo; Madrid, Carlos; Marcus, Noah J.; Schultz, Harold D.; and Del Rio, Rodrigo, "Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure." (2015). Journal Articles: Cellular & Integrative Physiology. 12.
https://digitalcommons.unmc.edu/com_cell_articles/12
Included in
Cellular and Molecular Physiology Commons, Medical Physiology Commons, Systems and Integrative Physiology Commons