Document Type
Article
Journal Title
BioMed research international
Publication Date
2013
Volume
2013
Abstract
As one of the leading causes of blindness, age-related macular degeneration (AMD) has remained at the epicenter of clinical research in ophthalmology. During the past decade, focus of researchers has ranged from understanding the role of vascular endothelial growth factor (VEGF) in the angiogenic cascades to developing new therapies for retinal vascular diseases. Anti-VEGF agents such as ranibizumab and aflibercept are becoming increasingly well-established therapies and have replaced earlier approaches such as laser photocoagulation or photodynamic therapy. Many other new therapeutic agents, which are in the early phase clinical trials, have shown promising results. The purpose of this paper is to briefly review the available treatment modalities for neovascular AMD and then focus on promising new therapies that are currently in various stages of development.
MeSH Headings
Angiogenesis Inhibitors, Animals, Antibodies, Monoclonal, Humanized, Humans, Macular Degeneration, Receptors, Vascular Endothelial Growth Factor, Recombinant Fusion Proteins, Retinal Neovascularization, Vascular Endothelial Growth Factor A
DOI Link
ISSN
2314-6141
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Hanout, Mostafa; Ferraz, Daniel; Ansari, Mehreen; Maqsood, Natasha; Kherani, Saleema; Sepah, Yasir J.; Rajagopalan, Nithya; Ibrahim, Mohamed; Do, Diana V.; and Dong Nguyen, Quan, "Therapies for neovascular age-related macular degeneration: current approaches and pharmacologic agents in development." (2013). Journal Articles: Ophthalmology. 5.
https://digitalcommons.unmc.edu/com_eye_articles/5