Age-related visual dynamics in HIV-infected adults with cognitive impairment.

Authors

Boman R. Groff, University of Nebraska Medical Center
Alex I. Wiesman, University of Nebraska Medical CenterFollow
Michael T. Rezich, University of Nebraska Medical Center
Jennifer O'Neill, University of Nebraska Medical CenterFollow
Kevin R. Robertson, University of Nebraska Medical Center
Howard S. Fox, University of Nebraska Medical CenterFollow
Susan Swindells, University of Nebraska Medical CenterFollow
Tony W. Wilson, University of Nebraska Medical CenterFollow

Document Type

Article

Journal Title

Neurology Neuroimmunology & Neuroinflammation

Publication Date

2020

Volume

7

Abstract

OBJECTIVE: To investigate whether aging differentially affects neural activity serving visuospatial processing in a large functional neuroimaging study of HIV-infected participants and to determine whether such aging effects are attributable to differences in the duration of HIV infection.

METHODS: A total of 170 participants, including 93 uninfected controls and 77 HIV-infected participants, underwent neuropsychological assessment followed by neuroimaging with magnetoencephalography (MEG). Time-frequency analysis of the MEG data followed by advanced image reconstruction of neural oscillatory activity and whole-brain statistical analyses were used to examine interactions between age, HIV infection, and cognitive status. Post hoc testing for a mediation effect of HIV infection duration on the relationship between age and neural activity was performed using a quasi-Bayesian approximation for significance testing.

RESULTS: Cognitively impaired HIV-infected participants were distinguished from unimpaired HIV-infected and control participants by their unique association between age and gamma oscillations in the parieto-occipital cortex. This relationship between age and gamma was fully mediated by the duration of HIV infection in cognitively impaired participants. Impaired HIV-infected participants were also distinguished by their atypical relationship between alpha oscillations and age in the superior parietal cortex.

CONCLUSIONS: Impaired HIV-infected participants exhibited markedly different relationships between age and neural responses in the parieto-occipital cortices relative to their peers. This suggests a differential effect of chronological aging on the neural bases of visuospatial processing in a cognitively impaired subset of HIV-infected adults. Some of these relationships were fully accounted for by differences in HIV infection duration, whereas others were more readily associated with aging.

DOI Link

10.1212/NXI.0000000000000690

ISSN

2332-7812

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Groff, Boman R.; Wiesman, Alex I.; Rezich, Michael T.; O'Neill, Jennifer; Robertson, Kevin R.; Fox, Howard S.; Swindells, Susan; and Wilson, Tony W., "Age-related visual dynamics in HIV-infected adults with cognitive impairment." (2020). Journal Articles: Internal Medicine. 12.
https://digitalcommons.unmc.edu/com_internal_articles/12