Document Type
Article
Journal Title
Frontiers in Nutrition
Publication Date
2024
Volume
11
Abstract
INTRODUCTION: Few studies have evaluated the effects of milk fat globule membrane (MFGM) on microbiota and immune markers in early infant nutrition.
METHODS: In this double-blind randomized study, infants (7-18 days of age) received either bovine milk-based infant formula (Control) or similar formula with an added source (5 g/L) of bovine MFGM (INV-MFGM) for 60 days. A reference group received mother's own human milk over the same period (HM). Oral and stool samples were collected (Baseline and Day 60) to evaluate microbiota, immune markers, and metabolites.
RESULTS: At Day 60, stool bacterial diversity and richness were higher in formula groups vs HM, as were
DISCUSSION: Overall, distinct patterns of stool metabolites and microbiota development were observed based on early nutrition.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT04059666.
DOI Link
ISSN
2296-861X
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Christensen, Chloe; Kok, Car Reen; Harris, Cheryl L.; Moore, Nancy; Wampler, Jennifer L.; Zhuang, Weihong; Wu, Steven S.; Hutkins, Robert; Izard, Jacques; and Auchtung, Jennifer M., "Microbiota, Metabolic Profiles and Immune Biomarkers in Infants Receiving Formula with Added Bovine Milk Fat Globule Membrane: A Randomized, Controlled Trial" (2024). Journal Articles: Internal Medicine. 29.
https://digitalcommons.unmc.edu/com_internal_articles/29
