The natural history of limited-stage peripheral T-cell lymphomas (PTCLs) remains poorly defined. We investigated outcomes and prognostic variables in patients registered in the T-Cell Project (TCP) (#NCT01142674) to develop a model to predict overall survival (OS) for the common nodal PTCL subtypes (PTCL-NOS, AITL, ALCL). The model was validated in an independent data set from Australian and Brazilian registries. 211 patients registered in the TCP between 2006-2018 were studied. The median age was 59 years (range 18-88) and median follow-up was 49 months. One hundred twenty-seven patients (78%) received anthracycline-based regimens, 5 patients (3%) radiotherapy alone (RT), 24 patients (15%) chemotherapy+RT. 5-year OS and PFS were 47% and 37%, respectively. Age >60 years, elevated LDH and low serum albumin were independent prognostic factors. The model identified 3 groups with low- (26%, score 0), intermediate- (41%, score 1), and high-risk (33%, score 2-3) with 5-year OS of 78% (95% confidence interval [95% CI], 29-127), 46% (95% CI, 24-68), and 25% (95% CI, 20-30), respectively (P < 0.001) and 5-year PFS of 66% (95% CI, 33-99), 37% (95% CI, 9-65), and 17% (95% CI, 9-25), respectively (P < 0.001). The model demonstrated greater discriminatory power than established prognostic indices and an analogous distribution and outcomes in the 3 groups in the validation cohort of 103 patients. The SALENTO Model (Limited Stage Peripheral T-Cell Lymphoma Prognostic Model) is an objective, simple and robust prognostic tool. The high-risk group has poor outcomes, comparable to advanced stage disease, and should be considered for innovative first-line approaches.
Humans, Infant, Child, Preschool, Child, Middle Aged, Lymphoma, T-Cell, Peripheral, Prognosis, Australia, T-Lymphocytes, Anthracyclines
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Hapgood, Greg; Civallero, Monica; Stepanishyna, Yana; Vose, Julie M.; Cabrera, Monica Elena; Advani, Ranjana H; Pileri, Stefano A.; Manni, Martina; Horwitz, Steven M.; Foss, Francine M.; Hitz, Felicitas; Radford, John; Dlouhy, Ivan; Chiattone, Carlos; Kim, Won Seog; Skrypets, Tetiana; Nagler, Arnon; Trotman, Judith; Luminari, Stefano; and Federico, Massimo, "The SALENTO Prognostic Model for Limited-Stage Peripheral T-Cell Lymphoma from the International T-Cell Project Network" (2023). Journal Articles: Oncology and Hematology. 10.