Document Type
Article
Journal Title
Frontiers in Immunology
Publication Date
2024
Volume
15
Abstract
INTRODUCTION: Significant neurologic morbidity is caused by pediatric cerebrospinal fluid (CSF) shunt infections. The underlying mechanisms leading to impaired school performance and increased risk of seizures are unknown, however, a better understanding of these mechanisms may allow us to temper their consequences. Recent evidence has demonstrated important roles for complement proteins in neurodevelopment and neuroinflammation.
METHODS: We examined complement activation throughout
RESULTS: We found that MASP2 predominated early in catheter infection, but that Factor B was elevated at intermediate time points. Unexpectedly C1q was elevated at late timepoints when bacterial burdens were low or undetectable. Based on these findings and the wealth of information regarding the emerging roles of C1q in the CNS, this suggests functions beyond pathogen elimination during
DISCUSSION: Neither C3 nor C5 impacted synaptic protein abundance. These findings suggest that chronic elevations in C1q in the brain that persist once CNS catheter infection has resolved may be modulating disease sequalae.
MeSH Headings
Animals, Staphylococcus epidermidis, Mice, Complement C1q, Staphylococcal Infections, Catheter-Related Infections, Disease Models, Animal, Mice, Inbred C57BL, Male, Complement Activation, Female, Chronic Disease, Mice, Knockout
DOI Link
ISSN
1664-3224
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Beaver, Matthew K.; Bergdolt, Lara; Dunaevsky, Anna; Kielian, Tammy; and Skar, Gwenn, "C1q is Elevated during Chronic Staphylococcus Epidermidis Central Nervous System Catheter Infection" (2024). Journal Articles: Pathology and Microbiology. 106.
https://digitalcommons.unmc.edu/com_pathmicro_articles/106