Prolonged-acting, multi-targeting gallium nanoparticles potently inhibit growth of both HIV and mycobacteria in co-infected human macrophages.

Authors

Prabagaran Narayanasamy, University of Nebraska Medical Center, OmahaFollow
Barbara L. Switzer, University of Nebraska Medical CenterFollow
Bradley E. Britigan, University of Nebraska Medical CenterFollow

Document Type

Article

Journal Title

Scientific Reports

Publication Date

Spring 3-6-2015

Volume

5

Abstract

Human immunodeficiency virus (HIV) infection and Mycobacterium tuberculosis (TB) are responsible for two of the major global human infectious diseases that result in significant morbidity, mortality and socioeconomic impact. Furthermore, severity and disease prevention of both infections is enhanced by co-infection. Parallel limitations also exist in access to effective drug therapy and the emergence of resistance. Furthermore, drug-drug interactions have proven problematic during treatment of co-incident HIV and TB infections. Thus, improvements in drug access and simplified treatment regimens are needed immediately. One of the key host cells infected by both HIV and TB is the mononuclear phagocyte (MP; monocyte, macrophage and dendritic cell). Therefore, we hypothesized that one way this can be achieved is through drug-targeting by a nanoformulated drug that ideally would be active against both HIV and TB. Accordingly, we validated macrophage targeted long acting (sustained drug release) gallium (Ga) nanoformulation against HIV-mycobacterium co-infection. The multi-targeted Ga nanoparticle agent inhibited growth of both HIV and TB in the macrophage. The Ga nanoparticles reduced the growth of mycobacterium and HIV for up to 15 days following single drug loading. These results provide a potential new approach to treat HIV-TB co-infection that could eventually lead to improved clinical outcomes.

MeSH Headings

Anti-HIV Agents, Antitubercular Agents, Cells, Cultured, Gallium, HIV-1, Humans, Macrophages, Metal Nanoparticles, Mycobacterium tuberculosis

DOI Link

10.1038/srep08824

ISSN

2045-2322

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Narayanasamy, Prabagaran; Switzer, Barbara L.; and Britigan, Bradley E., "Prolonged-acting, multi-targeting gallium nanoparticles potently inhibit growth of both HIV and mycobacteria in co-infected human macrophages." (2015). Journal Articles: Pathology and Microbiology. 6.
https://digitalcommons.unmc.edu/com_pathmicro_articles/6