Document Type
Article
Journal Title
Echo Research and Practice
Publication Date
2018
Abstract
INTRODUCTION: We compared right and left ventricular cardiac output (RVCO and LVCO) in fetuses of diabetic mothers (FDM) to a large normal cohort.
METHODS: We prospectively enrolled 264 normal fetuses and 30 FDM. Fetal CO parameters: semilunar valve velocity time integrals (AVVTI, PVVTI), ventricular outflow diameters (LVOTD, RVOTD), stroke volumes (AVSV, PVSV) were measured, and LVCO and RVCO calculated. These were normalized using nonlinear regression to estimated fetal weight (EFW) to provide means and standard deviations. Among FDMs, mean Z-scores and 95% confidence limits (CL) were calculated, and compared to zero.
RESULTS: LVCO, RVCO, and parameters they were calculated from, increased predictably and non-linearly with increasing EFW. In FDM, LVCO was depressed (mean Z -1.679, 95% CL -2.404, -0.955, p
CONCLUSION: Normal biventricular stroke volumes and outputs follow a nonlinear regression with EFW. FDM have significantly lower right and left heart stroke volumes and outputs for weight than do normal fetuses.
DOI Link
ISSN
2055-0464
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Winter, Jennifer; Kulkarni, Aparna; Craft, Mary; Li, Ling; Hornberger, Lisa K.; Danford, David A.; and Kutty, Shelby, "Depressed Left and Right Ventricular Cardiac Output in Fetuses of Diabetic Mothers" (2018). Journal Articles: Pediatrics. 12.
https://digitalcommons.unmc.edu/com_peds_articles/12