Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

Authors

Maranda Thompson, University of Nebraska Medical CenterFollow
Arzu Ulu, University of California, Riverside
Ana G. Yuil-Valdes, University of Nebraska Medical CenterFollow
Maheswari Mukherjee, University of Nebraska Medical CenterFollow
Melissa K. Thoene, University of Nebraska Medical CenterFollow
Matthew Van Ormer, University of Nebraska Medical CenterFollow
Rebecca Slotkowski, University of Nebraska Medical CenterFollow
Elizabeth Lyden, University of Nebraska Medical CenterFollow
Ann Anderson-Berry, University of Nebraska Medical CenterFollow
Corrine K. Hanson, University of Nebraska Medical CenterFollow
Tara M. Nordgren, University of California, Riverside
Sathish Kumar Natarajan, University of Nebraska - Lincoln

Document Type

Article

Journal Title

International Journal of Molecular Sciences

Publication Date

2022

Volume

23

Abstract

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography-tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman's correlations highlighted significant correlations between metabolite levels and infant growth. They were then adjusted for maternal obesity (normal body mass index (BMI: ≤30 kg/m²) vs. obese BMI (>30 kg/m²) and smoking status (never vs. current/former smoker) using linear regression modeling. A p-value < 0.05 was considered statistically significant. Our study demonstrated a diverse panel of oxylipins from the lipoxygenase pathway present at the time of delivery. In addition, both omega-3 and omega-6 oxylipins demonstrated potential influences on the birth length and weight percentiles. The oxylipins present during pregnancy may influence fetal growth and development, suggesting potential metabolites to be used as biomarkers for infant outcomes.

DOI Link

10.3390/ijms23020708

ISSN

1422-0067

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Thompson, Maranda; Ulu, Arzu; Yuil-Valdes, Ana G.; Mukherjee, Maheswari; Thoene, Melissa K.; Van Ormer, Matthew; Slotkowski, Rebecca; Lyden, Elizabeth; Anderson-Berry, Ann; Hanson, Corrine K.; Nordgren, Tara M.; and Natarajan, Sathish Kumar, "Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth" (2022). Journal Articles: Pediatrics. 28.
https://digitalcommons.unmc.edu/com_peds_articles/28