Document Type
Article
Journal Title
International Journal of Biomedical Imaging
Publication Date
Summer 7-22-2012
Volume
2012
Abstract
Purpose. To develop a technique to automate landmark selection for point-based interpolating transformations for nonlinear medical image registration. Materials and Methods. Interpolating transformations were calculated from homologous point landmarks on the source (image to be transformed) and target (reference image). Point landmarks are placed at regular intervals on contours of anatomical features, and their positions are optimized along the contour surface by a function composed of curvature similarity and displacements of the homologous landmarks. The method was evaluated in two cases (n = 5 each). In one, MRI was registered to histological sections; in the second, geometric distortions in EPI MRI were corrected. Normalized mutual information and target registration error were calculated to compare the registration accuracy of the automatically and manually generated landmarks. Results. Statistical analyses demonstrated significant improvement (P < 0.05) in registration accuracy by landmark optimization in most data sets and trends towards improvement (P < 0.1) in others as compared to manual landmark selection.
DOI Link
ISSN
1687-4196
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Recommended Citation
Liu, Yutong; Sajja, Balasrinivasa R.; Uberti, Mariano; Gendelman, Howard; Kielian, Tammy; and Boska, Michael D., "Landmark optimization using local curvature for point-based nonlinear rodent brain image registration." (2012). Journal Articles: Radiology. 7.
https://digitalcommons.unmc.edu/com_xray_articles/7