Document Type
Article
Journal Title
Lancet
Publication Date
2018
Volume
391
Abstract
The 2013-16 Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care, and limitations in the provision of supportive medical care. Case fatality rates in west Africa were initially greater than 70%, but decreased with improvements in supportive care. To inform optimal care in a future outbreak of Ebola virus disease, we employed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to develop evidence-based guidelines for the delivery of supportive care to patients admitted to Ebola treatment units. Key recommendations include administration of oral and, as necessary, intravenous hydration; systematic monitoring of vital signs and volume status; availability of key biochemical testing; adequate staffing ratios; and availability of analgesics, including opioids, for pain relief.
DOI Link
ISSN
1474-547X
Creative Commons License
This work is licensed under a
Creative Commons Public Domain Dedication 1.0 License.
Rights
U.S. Government Work
Recommended Citation
Lamontagne, François; Fowler, Robert A.; Adhikari, Neill K.; Murthy, Srinivas; Brett-Major, David; Jacobs, Michael; Uyeki, Timothy M.; Vallenas, Constanza; Norris, Susan L.; Fischer, William A.; Fletcher, Thomas E.; Levine, Adam C.; Reed, Paul; Bausch, Daniel G.; Gove, Sandy; Hall, Andrew; Shepherd, Susan; Siemieniuk, Reed A.; Lamah, Marie-Claude; Kamara, Rashida; Nakyeyune, Phiona; Soka, Moses J.; Edwin, Ama; Hazzan, Afeez A.; Jacob, Shevin T.; Elkarsany, Mubarak Mustafa; Adachi, Takuya; Benhadj, Lynda; Clément, Christophe; Crozier, Ian; Garcia, Armando; Hoffman, Steven J.; and Guyatt, Gordon H., "Evidence-Based Guidelines for Supportive Care of Patients with Ebola Virus Disease" (2018). Journal Articles: Epidemiology. 37.
https://digitalcommons.unmc.edu/coph_epidem_articles/37