The Induction of Autoimmune Arthritis and Sex differences in Mice Impact the Lung Inflammatory Response to Repetitive Inhalant Organic Dust Extract Exposures

Authors

Kathryn Rentfro, University of Nebraska Medical Center
Geoffrey M. Thiele, University of Nebraska Medical CenterFollow
Katherine Janike, University of Nebraska Medical Center
Amy J. Nelson, University of Nebraska Medical CenterFollow
Michael J. Duryee, University of Nebraska Medical CenterFollow
Bryant R. England, University of Nebraska Medical CenterFollow
Debra J. Romberger, University of Nebraska Medical CenterFollow
Joseph Carrington, University of Nebraska Medical Center
Dong Wang, University of Nebraska Medical CenterFollow
Benjamin J. Swanson, University of Nebraska Medical CenterFollow
Lynell W. Klassen, University of Nebraska Medical CenterFollow
Ted R. Mikuls, University of Nebraska Medical CenterFollow
Jill A. Poole, University of Nebraska Medical CenterFollow

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Abstract or Description

Asthma, chronic bronchitis and COPD are common adverse respiratory health effects among persons exposed to agriculture organic dust work environments.

• Occupational inhalant exposures have been increasingly associated with the risk of rheumatoid arthritis (RA) disease development, particularly among males. Agriculture workers have increased risk of RA and generalized bone disease.
• Chronic lung disease is associated with production of characteristic autoantibodies associated with RA (e.g.anti-citrullinated antibodies), even in absence of RA disease.
• The mechanistic link between pulmonary inflammation and arthritis (and vice versa) remains poorly understood. Animal models are lacking.

Publication Date

2021

Disciplines

Medical Education

Recommended Citation

Rentfro, Kathryn; Thiele, Geoffrey M.; Janike, Katherine; Nelson, Amy J.; Duryee, Michael J.; England, Bryant R.; Romberger, Debra J.; Carrington, Joseph; Wang, Dong; Swanson, Benjamin J.; Klassen, Lynell W.; Mikuls, Ted R.; and Poole, Jill A., "The Induction of Autoimmune Arthritis and Sex differences in Mice Impact the Lung Inflammatory Response to Repetitive Inhalant Organic Dust Extract Exposures" (2021). EMET Projects. 5.
https://digitalcommons.unmc.edu/emet_posters/5