Document Type
Article
Journal Title
Biochemical and Biophysical Research Communications
Publication Date
2018
Volume
501
Abstract
We discovered that SU11274, a class I c-Met inhibitor, fluoresces when excited by 488 nm laser light and showed rapid specific accumulation in distinct subcellular compartments. Given that SU11274 reduces cancer cell viability, we exploited these newly identified spectral properties to determine SU11274 intracellular distribution and accumulation in human pancreatic cancer cells. The aim of the studies reported here was to identify organelle(s) to which SU11274 is trafficked. We conclude that SU11274 rapidly and predominantly accumulates in the endoplasmic reticulum.
MeSH Headings
Biological Transport, Cell Line, Tumor, Endoplasmic Reticulum, Fluorescence, Humans, Indoles, Piperazines, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-met, Subcellular Fractions, Sulfonamides
DOI Link
ISSN
1090-2104
Recommended Citation
Wiest, Edwin J.; Jensen Smith, Heather; and Hollingsworth, Michael A., "Met Receptor Inhibitor SU11274 Localizes in the Endoplasmic Reticulum" (2018). Journal Articles: Eppley Institute. 52.
https://digitalcommons.unmc.edu/eppley_articles/52
Comments
Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Apr 20. Published in final edited form as: Biochem Biophys Res Commun. 2018 Jul 2; 501(4): 858–862.