Graduation Date

Summer 8-12-2022

Document Type


Degree Name

Master of Science (MS)


Molecular Genetics & Cell Biology

First Advisor

Gargi Ghosal

Second Advisor

Andrew Dudley

Third Advisor

Jordan Rowley


Ewing Sarcoma is an aggressive cancer characterized by a fusion gene formed from a chromosomal translocation between a RNA binding protein and a transcription factor. The most common fusion gene is EWS-FLI1 a potent oncogenic transcription factor responsible for initiating genome instability. EWS-FLI1 promotes tumor growth by dysregulating several genes and pathways. We have identified FOXN3, an important gene in cell cycle control and development, as being suppressed by EWS-FLI1. In the future, a better understanding of FOXN3 and its ability to act as a tumor suppressor in EWS will unravel novel mechanisms of EWS pathogenesis, potential biomarker and drug target in Ewing sarcoma.

Available for download on Wednesday, July 24, 2024