Master of Science (MS)
Molecular Genetics & Cell Biology
Ewing Sarcoma is an aggressive cancer characterized by a fusion gene formed from a chromosomal translocation between a RNA binding protein and a transcription factor. The most common fusion gene is EWS-FLI1 a potent oncogenic transcription factor responsible for initiating genome instability. EWS-FLI1 promotes tumor growth by dysregulating several genes and pathways. We have identified FOXN3, an important gene in cell cycle control and development, as being suppressed by EWS-FLI1. In the future, a better understanding of FOXN3 and its ability to act as a tumor suppressor in EWS will unravel novel mechanisms of EWS pathogenesis, potential biomarker and drug target in Ewing sarcoma.
Kreiling, Natasha, "Ewing Sarcoma Transcriptome: Identification of FOXN3 as a Novel Target of EWS-FLI1" (2022). Theses & Dissertations. 669.
Available for download on Wednesday, July 24, 2024