ORCID ID
Graduation Date
Summer 8-12-2022
Document Type
Thesis
Degree Name
Master of Science (MS)
Programs
Medical Sciences Interdepartmental Area
First Advisor
Daryl J Murray, PharmD
Second Advisor
Kim Scarsi, PharmD
Third Advisor
Keith Olsen, PharmD
Abstract
A series of studies within the setting of extracorporeal membrane oxygenation (ECMO) was undertaken to specifically answer questions related to medication optimization during this complex therapy. These studies included medication therapies involving optimal anticoagulation, analgesia delivery, fluid resuscitation, and infection related outcomes in the context of ECMO. Each investigation was retrospective in nature and included patients from a single institution. The results of these studies indicated the following: 1.) various anticoagulation goals do not impact severe, life-threatening bleeding events during ECMO therapy; 2.) sepsis is a common occurrence in the setting of ECMO; 3.) the choice of either a crystalloid or albumin dense resuscitation effort does not impact fluid balance within 48 hours of ECMO cannulation, and 4.) that the utilization of hydromorphone analgesia during ECMO results in less opioid exposure compared to fentanyl therapy. This research undertaken presents a foundation to continue further studies in this complex landscape. Future studies including prospective analysis would aid in the most objective understanding of optimal pharmaceutical care during ECMO utilization.
Recommended Citation
Peitz, Greg, "Evaluation of medication optimization in the setting of ECMO therapy: assessment of therapeutic effectiveness" (2022). Theses & Dissertations. 672.
https://digitalcommons.unmc.edu/etd/672
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Wolters Kluwer Copyright figures and tables - GPeitz Thesis.pdf (181 kB)
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