EHD2 Promotes Store-Operated Calcium Entry (SOCE) and Cellular Migration in Ovarian Cancer Cells

Author

Mariam Zahid, University of Nebraska Medical CenterFollow
Haitao Luan, University of Nebraska Medical Center
Bhopal C. Mohapatra, University of Nebraska Medical Center
Aaqib Bhat, University of Nebraska Medical Center
Sukanya Chakraborty, University of Nebraska Medical Center
Oscar D. Juvera, University of Nebraska Medical Center
Matthew Storck, University of Nebraska Medical CenterFollow
Vimla Band, University of Nebraska Medical Center
Hamid Band, University of Nebraska Medical Center

Files

Presentation date

Summer 8-10-2023

College, Institute, or Department

Eppley Institute for Research in Cancer

Faculty Mentor

Haitao Luan, PhD.

Research Mentor

Hamid Band, MD-PhD.

Abstract

Ovarian cancer (OC) ranks as the 5th most common cause of cancer deaths of women, reflecting late diagnoses and lack of targeted therapies. EHD2, a member of the Eps15 homology (EH) domain containing (EHD) proteins family, regulates cell surface expression of Orai1, the mediator of store-operated calcium entry (SOCE) in breast cancer. Disrupting the EHD2-Orai1 axis in OC could provide novel targeted therapies against metastatic disease.

Keywords

Ovarian Cancer, EHD2, EHD (Eps15 homology domain), Store Operated Calcium Entry, SOCE

Recommended Citation

Zahid, Mariam; Luan, Haitao; Mohapatra, Bhopal C.; Bhat, Aaqib; Chakraborty, Sukanya; Juvera, Oscar D.; Storck, Matthew; Band, Vimla; and Band, Hamid, "EHD2 Promotes Store-Operated Calcium Entry (SOCE) and Cellular Migration in Ovarian Cancer Cells" (2023). Posters: 2023 Summer Undergraduate Research Program. 2.
https://digitalcommons.unmc.edu/surp2023/2