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Presentation date

Summer 8-10-2023

College, Institute, or Department

Eppley Institute for Research in Cancer

Faculty Mentor

Haitao Luan, PhD.

Research Mentor

Hamid Band, MD-PhD.


Ovarian cancer (OC) ranks as the 5th most common cause of cancer deaths of women, reflecting late diagnoses and lack of targeted therapies. EHD2, a member of the Eps15 homology (EH) domain containing (EHD) proteins family, regulates cell surface expression of Orai1, the mediator of store-operated calcium entry (SOCE) in breast cancer. Disrupting the EHD2-Orai1 axis in OC could provide novel targeted therapies against metastatic disease.


Ovarian Cancer, EHD2, EHD (Eps15 homology domain), Store Operated Calcium Entry, SOCE

EHD2 Promotes Store-Operated Calcium Entry (SOCE) and Cellular Migration in Ovarian Cancer Cells