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College, Institute, or Department
Eppley Institute for Research in Cancer
Haitao Luan, PhD.
Hamid Band, MD-PhD.
Ovarian cancer (OC) ranks as the 5th most common cause of cancer deaths of women, reflecting late diagnoses and lack of targeted therapies. EHD2, a member of the Eps15 homology (EH) domain containing (EHD) proteins family, regulates cell surface expression of Orai1, the mediator of store-operated calcium entry (SOCE) in breast cancer. Disrupting the EHD2-Orai1 axis in OC could provide novel targeted therapies against metastatic disease.
Ovarian Cancer, EHD2, EHD (Eps15 homology domain), Store Operated Calcium Entry, SOCE
Zahid, Mariam; Luan, Haitao; Mohapatra, Bhopal C.; Bhat, Aaqib; Chakraborty, Sukanya; Juvera, Oscar D.; Storck, Matthew; Band, Vimla; and Band, Hamid, "EHD2 Promotes Store-Operated Calcium Entry (SOCE) and Cellular Migration in Ovarian Cancer Cells" (2023). Posters: 2023 Summer Undergraduate Research Program. 2.