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Theses/Dissertations from 2022

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Investigating the Role of Splenic Macrophages in Pancreatic Cancer, Daisy V. Gonzalez

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Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer, Shelby M. Knoche

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Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells, Cassie Liu

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SOX2 Dosage Governs Tumor Cell Identity and Proliferation, Ethan P. Metz

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Post-Transcriptional Control of the Epithelial-to-Mesenchymal Transition (EMT) in Ras-Driven Colorectal Cancers, Chaitra Rao

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Use of Machine Learning Algorithms and Highly Multiplexed Immunohistochemistry to Perform In-Depth Characterization of Primary Pancreatic Tumors and Metastatic Sites, Krysten Vance

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Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling, Pauline Xu

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Phos-Tag-Based Screens Identify Novel Therapeutic Targets in Ovarian Cancer and Pancreatic Cancer, Renya Zeng

Theses/Dissertations from 2021

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Functional Characterization of Cancer-Associated DNA Polymerase ε Variants, Stephanie R. Barbari

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Pancreatic Cancer: Novel Therapy, Research Tools, and Educational Outreach, Ayrianne J. Crawford

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Apixaban to Prevent Thrombosis in Adult Patients Treated With Asparaginase, Krishna Gundabolu

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Molecular Investigation into the Biologic and Prognostic Elements of Peripheral T-cell Lymphoma with Regulators of Tumor Microenvironment Signaling Explored in Model Systems, Tyler Herek

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Utilizing Proteolysis-Targeting Chimeras to Target the Transcriptional Cyclin-Dependent Kinases 9 and 12, Hannah King

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Insights into Cutaneous Squamous Cell Carcinoma Pathogenesis and Metastasis Using a Bedside-to-Bench Approach, Marissa Lobl

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Development of a MUC16-Targeted Near-Infrared Antibody Probe for Fluorescence-Guided Surgery of Pancreatic Cancer, Madeline T. Olson

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FGFR4 glycosylation and processing in cholangiocarcinoma promote cancer signaling, Andrew J. Phillips

Theses/Dissertations from 2020

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Cooperativity of CCNE1 and FOXM1 in High-Grade Serous Ovarian Cancer, Lucy Elge

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Characterizing the critical role of metabolic and redox homeostasis in colorectal cancer, Danielle Frodyma

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Genomic and Transcriptomic Alterations in Metabolic Regulators and Implications for Anti-tumoral Immune Response, Ryan J. King

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Dimers of Isatin Derived Spirocyclic NF-κB Inhibitor Exhibit Potent Anticancer Activity by Inducing UPR Mediated Apoptosis, Smit Kour

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From Development to Therapy: A Panoramic Approach to Further Our Understanding of Cancer, Brittany Poelaert

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The Cellular Origin and Molecular Drivers of Claudin-Low Mammary Cancer, Patrick D. Raedler

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Mitochondrial Metabolism as a Therapeutic Target for Pancreatic Cancer, Simon Shin

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Development of Fluorescent Hyaluronic Acid Nanoparticles for Intraoperative Tumor Detection, Nicholas E. Wojtynek

Theses/Dissertations from 2019

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The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis, R. Willow Hynes-Smith

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BRCA1 & CTDP1 BRCT Domainomics in the DNA Damage Response, Kimiko L. Krieger

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Targeted Inhibition of Histone Deacetyltransferases for Pancreatic Cancer Therapy, Richard Laschanzky

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Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration, Bailee Sliker

Theses/Dissertations from 2018

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FOXM1 Expression and Contribution to Genomic Instability and Chemoresistance in High-Grade Serous Ovarian Cancer, Carter J. Barger

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Overcoming TCF4-Driven BCR Signaling in Diffuse Large B-Cell Lymphoma, Keenan Hartert

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Functional Role of Protein Kinase C Alpha in Endometrial Carcinogenesis, Alice Hsu

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Functional Signature Ontology-Based Identification and Validation of Novel Therapeutic Targets and Natural Products for the Treatment of Cancer, Beth Neilsen

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Elucidating the Roles of Lunatic Fringe in Pancreatic Ductal Adenocarcinoma, Prathamesh Patil

Theses/Dissertations from 2017

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Metabolic Reprogramming of Pancreatic Ductal Adenocarcinoma Cells in Response to Chronic Low pH Stress, Jaime Abrego

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Understanding the Relationship between TGF-Beta and IGF-1R Signaling in Colorectal Cancer, Katie L. Bailey

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The Role of EHD2 in Triple-Negative Breast Cancer Tumorigenesis and Progression, Timothy A. Bielecki

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Perturbing anti-apoptotic proteins to develop novel cancer therapies, Jacob Contreras

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Role of Ezrin in Colorectal Cancer Cell Survival Regulation, Premila Leiphrakpam

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Evaluation of Aminopyrazole Analogs as Cyclin-Dependent Kinase Inhibitors for Colorectal Cancer Therapy, Caroline Robb

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Identifying the Role of Janus Kinase 1 in Mammary Gland Development and Breast Cancer, Barbara Swenson

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DNMT3A Haploinsufficiency Provokes Hematologic Malignancy of B-Lymphoid, T-Lymphoid, and Myeloid Lineage in Mice, Garland Michael Upchurch

Theses/Dissertations from 2016

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EHD1 As a Positive Regulator of Macrophage Colony-Stimulating Factor-1 Receptor, Luke R. Cypher

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Inflammation- and Cancer-Associated Neurolymphatic Remodeling and Cachexia in Pancreatic Ductal Adenocarcinoma, Darci M. Fink

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Role of CBL-family Ubiquitin Ligases as Critical Negative Regulators of T Cell Activation and Functions, Benjamin Goetz

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Exploration into the Functional Impact of MUC1 on the Formation and Regulation of Transcriptional Complexes Containing AP-1 and p53, Ryan L. Hanson

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DNA Polymerase Zeta-Dependent Mutagenesis: Molecular Specificity, Extent of Error-Prone Synthesis, and the Role of dNTP Pools, Olga V. Kochenova

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Defining the Role of Phosphorylation and Dephosphorylation in the Regulation of Gap Junction Proteins, Hanjun Li

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Molecular Mechanisms Regulating MYC and PGC1β Expression in Colon Cancer, Jamie L. McCall

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Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4, Maria M. Steele

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Altered Levels of SOX2, and Its Associated Protein Musashi2, Disrupt Critical Cell Functions in Cancer and Embryonic Stem Cells, Erin L. Wuebben

Theses/Dissertations from 2015

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Characterization and target identification of non-toxic IKKβ inhibitors for anticancer therapy, Elizabeth Blowers

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Effectors of Ras and KSR1 dependent colon tumorigenesis, Binita Das

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Characterization of cancer-associated DNA polymerase delta variants, Tony M. Mertz

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A Role for EHD Family Endocytic Regulators in Endothelial Biology, Alexandra E. J. Moffitt

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Biochemical pathways regulating mammary epithelial cell homeostasis and differentiation, Chandrani Mukhopadhyay

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EPACs: epigenetic regulators that affect cell survival in cancer., Catherine Murari

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Role of the C-terminus of the Catalytic Subunit of Translesion Synthesis Polymerase ζ (Zeta) in UV-induced Mutagensis, Hollie M. Siebler

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LGR5 Activates TGFbeta Signaling and Suppresses Metastasis in Colon Cancer, Xiaolin Zhou

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LGR5 Activates TGFβ Signaling and Suppresses Metastasis in Colon Cancer, Xiaolin Zhou

Theses/Dissertations from 2014

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Genetic dissection of the role of CBL-family ubiquitin ligases and their associated adapters in epidermal growth factor receptor endocytosis, Gulzar Ahmad

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Strategies for the identification of chemical probes to study signaling pathways, Jamie Leigh Arnst

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Defining the mechanism of signaling through the C-terminus of MUC1, Roger B. Brown

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Targeting telomerase in human pancreatic cancer cells, Katrina Burchett

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The identification of KSR1-like molecules in ras-addicted colorectal cancer cells, Drew Gehring

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Mechanisms of regulation of AID APOBEC deaminases activity and protection of the genome from promiscuous deamination, Artem Georgievich Lada

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Characterization of the DNA-biding properties of human telomeric proteins, Amanda Lakamp-Hawley

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Studies on MUC1, p120-catenin, Kaiso: coordinate role of mucins, cell adhesion molecules and cell cycle players in pancreatic cancer, Xiang Liu

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Epac interaction with the TGFbeta PKA pathway to regulate cell survival in colon cancer, Meghan Lynn Mendick

Theses/Dissertations from 2013

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Deconvolution of the phosphorylation patterns of replication protein A by the DNA damage response to breaks, Kerry D. Brader

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Modeling malignant breast cancer occurrence and survival in black and white women, Michael Gleason

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The role of dna methyltransferases in myc-induced lymphomagenesis, Ryan A. Hlady

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Design and development of inhibitors of CBL (TKB)-protein interactions, Eric A. Kumar

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Pancreatic cancer-associated miRNAs : expression, regulation and function, Ashley M. Mohr

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Mechanistic studies of mitochondrial outer membrane permeabilization (MOMP), Xiaming Pang

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Novel roles for JAK2/STAT5 signaling in mammary gland development, cancer, and immune dysregulation, Jeffrey Wayne Schmidt

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Optimization of therapeutics against lethal pancreatic cancer, Joshua J. Souchek

Theses/Dissertations from 2012

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Immune-based novel diagnostic mechanisms for pancreatic cancer, Michael J. Baine

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Sox2 associated proteins are essential for cell fate, Jesse Lee Cox

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KSR2 regulates cellular proliferation, transformation, and metabolism, Mario R. Fernandez

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Discovery of a novel signaling cross-talk between TPX2 and the aurora kinases during mitosis, Jyoti Iyer

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Regulation of metabolism by KSR proteins, Paula Jean Klutho

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The role of ERK 1/2 signaling in the dna damage-induced G2, Ryan Kolb

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Regulation of the Bcl-2 family network during apoptosis induced by different stimuli, Hernando Lopez

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Studies on the role of cullin3 in mitosis, Saili Moghe

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Characteristics of amyloid precursor-like protein 2 (APLP2) in pancreatic cancer and Ewing's sarcoma, Haley Louise Capek Peters

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Structural and biophysical analysis of a human inosine triphosphate pyrophosphatase polymorphism, Peter David Simone

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Functions and regulation of Ron receptor tyrosine kinase in human pancreatic cancer and its therapeutic applications, Yi Zou

Theses/Dissertations from 2011

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Coordinate detection of new targets and small molecules for cancer therapy, Kurt Fisher

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The role of c-Myc in pancreatic cancer initiation and progression, Wan-Chi Lin

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The role of inosine triphosphate pyrophosphatase (ITPA) in maintanence [sic] of genomic stability in human cells, Miriam-Rose Menezes

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Molecular insights into major histocompatibility complex class I folding and assembly, Laura Christina Simone

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The role of bcl-2 in colon cancer metastatic progression, Wang Wang

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A rational peptidomimetic approach towards generation of high affinity BRCT (BRCA1) inhibitors, Ziyan Yuan

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D-type cyclins and breast cancer, Quian Zhang

Theses/Dissertations from 2010

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Cell survival and metastasis regulation by TGFß/PKA signaling, Sanjib Chowdhury

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Cyclin dependent kinase 5 contributes to the progression of pancreatic cancer, John Eggers

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Roles of XPF-ERCC1 in dna repair, Laura A. Fisher

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Cell cycle control and spatio-temporal regulation of erk signaling by ksr1, Heidi Jo Johnson

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Regulation and function of Oct-3/4 and Sox2 in embryonal carcinoma and embryonic stem cells, Sunil Kumar Mallanna

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Binding studies of human single-stranded dna binding and repair proteins : replication protein A and RAD52, Aishwarya Prakash