Theses/Dissertations from 2024
Therapeutic Effects of BET Protein Inhibition in B-cell Malignancies and Beyond, Audrey L. Smith
Identification of Mitotic Phosphatases and Cyclin K as Novel Molecular Targets in Pancreatic Cancer, Yi Xiao
Theses/Dissertations from 2023
Development of Combination Therapy Strategies to Treat Cancer Using Dihydroorotate Dehydrogenase Inhibitors, Nicholas Mullen
Overcoming Resistance Mechanisms to CDK4/6 Inhibitor Treatment Using CDK6-Selective PROTAC, Sarah Truong
Theses/Dissertations from 2022
Omics Analysis in Cancer and Development, Emalie J. Clement
Investigating the Role of Splenic Macrophages in Pancreatic Cancer, Daisy V. Gonzalez
Polymeric Chloroquine in Metastatic Pancreatic Cancer Therapy, Rubayat Islam Khan
Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer, Shelby M. Knoche
Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells, Cassie Liu
Novel Mechanisms of Protein Kinase C α Regulation and Function, Xinyue Li
SOX2 Dosage Governs Tumor Cell Identity and Proliferation, Ethan P. Metz
Post-Transcriptional Control of the Epithelial-to-Mesenchymal Transition (EMT) in Ras-Driven Colorectal Cancers, Chaitra Rao
Characterization of Metastatic Cutaneous Squamous Cell Carcinoma in the Immunosuppressed Patient, Megan E. Wackel
Phos-Tag-Based Screens Identify Novel Therapeutic Targets in Ovarian Cancer and Pancreatic Cancer, Renya Zeng
Theses/Dissertations from 2021
Functional Characterization of Cancer-Associated DNA Polymerase ε Variants, Stephanie R. Barbari
Pancreatic Cancer: Novel Therapy, Research Tools, and Educational Outreach, Ayrianne J. Crawford
Apixaban to Prevent Thrombosis in Adult Patients Treated With Asparaginase, Krishna Gundabolu
Utilizing Proteolysis-Targeting Chimeras to Target the Transcriptional Cyclin-Dependent Kinases 9 and 12, Hannah King
Insights into Cutaneous Squamous Cell Carcinoma Pathogenesis and Metastasis Using a Bedside-to-Bench Approach, Marissa Lobl
Development of a MUC16-Targeted Near-Infrared Antibody Probe for Fluorescence-Guided Surgery of Pancreatic Cancer, Madeline T. Olson
FGFR4 glycosylation and processing in cholangiocarcinoma promote cancer signaling, Andrew J. Phillips
Theses/Dissertations from 2020
Cooperativity of CCNE1 and FOXM1 in High-Grade Serous Ovarian Cancer, Lucy Elge
Characterizing the critical role of metabolic and redox homeostasis in colorectal cancer, Danielle Frodyma
Genomic and Transcriptomic Alterations in Metabolic Regulators and Implications for Anti-tumoral Immune Response, Ryan J. King
From Development to Therapy: A Panoramic Approach to Further Our Understanding of Cancer, Brittany Poelaert
The Cellular Origin and Molecular Drivers of Claudin-Low Mammary Cancer, Patrick D. Raedler
Mitochondrial Metabolism as a Therapeutic Target for Pancreatic Cancer, Simon Shin
Development of Fluorescent Hyaluronic Acid Nanoparticles for Intraoperative Tumor Detection, Nicholas E. Wojtynek
Theses/Dissertations from 2019
The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis, R. Willow Hynes-Smith
BRCA1 & CTDP1 BRCT Domainomics in the DNA Damage Response, Kimiko L. Krieger
Targeted Inhibition of Histone Deacetyltransferases for Pancreatic Cancer Therapy, Richard Laschanzky
Theses/Dissertations from 2018
FOXM1 Expression and Contribution to Genomic Instability and Chemoresistance in High-Grade Serous Ovarian Cancer, Carter J. Barger
Overcoming TCF4-Driven BCR Signaling in Diffuse Large B-Cell Lymphoma, Keenan Hartert
Functional Role of Protein Kinase C Alpha in Endometrial Carcinogenesis, Alice Hsu
Elucidating the Roles of Lunatic Fringe in Pancreatic Ductal Adenocarcinoma, Prathamesh Patil
Theses/Dissertations from 2017
Metabolic Reprogramming of Pancreatic Ductal Adenocarcinoma Cells in Response to Chronic Low pH Stress, Jaime Abrego
Understanding the Relationship between TGF-Beta and IGF-1R Signaling in Colorectal Cancer, Katie L. Bailey
The Role of EHD2 in Triple-Negative Breast Cancer Tumorigenesis and Progression, Timothy A. Bielecki
Perturbing anti-apoptotic proteins to develop novel cancer therapies, Jacob Contreras
Role of Ezrin in Colorectal Cancer Cell Survival Regulation, Premila Leiphrakpam
Evaluation of Aminopyrazole Analogs as Cyclin-Dependent Kinase Inhibitors for Colorectal Cancer Therapy, Caroline Robb
Identifying the Role of Janus Kinase 1 in Mammary Gland Development and Breast Cancer, Barbara Swenson
DNMT3A Haploinsufficiency Provokes Hematologic Malignancy of B-Lymphoid, T-Lymphoid, and Myeloid Lineage in Mice, Garland Michael Upchurch
Theses/Dissertations from 2016
EHD1 As a Positive Regulator of Macrophage Colony-Stimulating Factor-1 Receptor, Luke R. Cypher
Inflammation- and Cancer-Associated Neurolymphatic Remodeling and Cachexia in Pancreatic Ductal Adenocarcinoma, Darci M. Fink
Role of CBL-family Ubiquitin Ligases as Critical Negative Regulators of T Cell Activation and Functions, Benjamin Goetz
Exploration into the Functional Impact of MUC1 on the Formation and Regulation of Transcriptional Complexes Containing AP-1 and p53, Ryan L. Hanson
DNA Polymerase Zeta-Dependent Mutagenesis: Molecular Specificity, Extent of Error-Prone Synthesis, and the Role of dNTP Pools, Olga V. Kochenova
Molecular Mechanisms Regulating MYC and PGC1β Expression in Colon Cancer, Jamie L. McCall
Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4, Maria M. Steele
Altered Levels of SOX2, and Its Associated Protein Musashi2, Disrupt Critical Cell Functions in Cancer and Embryonic Stem Cells, Erin L. Wuebben
Theses/Dissertations from 2015
Characterization and target identification of non-toxic IKKβ inhibitors for anticancer therapy, Elizabeth Blowers
Effectors of Ras and KSR1 dependent colon tumorigenesis, Binita Das
Characterization of cancer-associated DNA polymerase delta variants, Tony M. Mertz
A Role for EHD Family Endocytic Regulators in Endothelial Biology, Alexandra E. J. Moffitt
Biochemical pathways regulating mammary epithelial cell homeostasis and differentiation, Chandrani Mukhopadhyay
EPACs: epigenetic regulators that affect cell survival in cancer., Catherine Murari
Role of the C-terminus of the Catalytic Subunit of Translesion Synthesis Polymerase ζ (Zeta) in UV-induced Mutagensis, Hollie M. Siebler
LGR5 Activates TGFbeta Signaling and Suppresses Metastasis in Colon Cancer, Xiaolin Zhou
LGR5 Activates TGFβ Signaling and Suppresses Metastasis in Colon Cancer, Xiaolin Zhou
Theses/Dissertations from 2014
Strategies for the identification of chemical probes to study signaling pathways, Jamie Leigh Arnst
Defining the mechanism of signaling through the C-terminus of MUC1, Roger B. Brown
Targeting telomerase in human pancreatic cancer cells, Katrina Burchett
The identification of KSR1-like molecules in ras-addicted colorectal cancer cells, Drew Gehring
Mechanisms of regulation of AID APOBEC deaminases activity and protection of the genome from promiscuous deamination, Artem Georgievich Lada
Characterization of the DNA-biding properties of human telomeric proteins, Amanda Lakamp-Hawley
Epac interaction with the TGFbeta PKA pathway to regulate cell survival in colon cancer, Meghan Lynn Mendick
Theses/Dissertations from 2013
Deconvolution of the phosphorylation patterns of replication protein A by the DNA damage response to breaks, Kerry D. Brader
Modeling malignant breast cancer occurrence and survival in black and white women, Michael Gleason
The role of dna methyltransferases in myc-induced lymphomagenesis, Ryan A. Hlady
Design and development of inhibitors of CBL (TKB)-protein interactions, Eric A. Kumar
Pancreatic cancer-associated miRNAs : expression, regulation and function, Ashley M. Mohr
Mechanistic studies of mitochondrial outer membrane permeabilization (MOMP), Xiaming Pang
Novel roles for JAK2/STAT5 signaling in mammary gland development, cancer, and immune dysregulation, Jeffrey Wayne Schmidt
Optimization of therapeutics against lethal pancreatic cancer, Joshua J. Souchek
Theses/Dissertations from 2012
Immune-based novel diagnostic mechanisms for pancreatic cancer, Michael J. Baine
Sox2 associated proteins are essential for cell fate, Jesse Lee Cox
KSR2 regulates cellular proliferation, transformation, and metabolism, Mario R. Fernandez
Discovery of a novel signaling cross-talk between TPX2 and the aurora kinases during mitosis, Jyoti Iyer
Regulation of metabolism by KSR proteins, Paula Jean Klutho
The role of ERK 1/2 signaling in the dna damage-induced G2, Ryan Kolb
Regulation of the Bcl-2 family network during apoptosis induced by different stimuli, Hernando Lopez
Studies on the role of cullin3 in mitosis, Saili Moghe
Characteristics of amyloid precursor-like protein 2 (APLP2) in pancreatic cancer and Ewing's sarcoma, Haley Louise Capek Peters
Structural and biophysical analysis of a human inosine triphosphate pyrophosphatase polymorphism, Peter David Simone
Theses/Dissertations from 2011
Coordinate detection of new targets and small molecules for cancer therapy, Kurt Fisher
The role of c-Myc in pancreatic cancer initiation and progression, Wan-Chi Lin
The role of inosine triphosphate pyrophosphatase (ITPA) in maintanence [sic] of genomic stability in human cells, Miriam-Rose Menezes
Molecular insights into major histocompatibility complex class I folding and assembly, Laura Christina Simone
The role of bcl-2 in colon cancer metastatic progression, Wang Wang