Document Type
Article
Journal Title
Advances in Cancer Biology - Metastasis
Publication Date
2023
Volume
7
Abstract
Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.
ISSN
2667-3940
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Benjamin, Mercilena; Malakar, Pushkar; Sinha, Rohit Anthony; Nasser, Mohd Wasim; Batra, Surinder K.; Siddiqui, Jawed A.; and Chakravarti, Bandana, "Molecular Signaling Network and Therapeutic Developments in Breast Cancer Brain Metastasis" (2023). Journal Articles: Biochemistry & Molecular Biology. 159.
https://digitalcommons.unmc.edu/com_bio_articles/159