Document Type
Article
Journal Title
Molecular Cancer
Publication Date
2023
Volume
22
Abstract
The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is nothing less than a death sentence, with few treatment options for palliation or prolonging life. Among the few treatment options available, brain radiotherapy (RT) and surgical resection have been the backbone of therapy. Within the past couple of years, immunotherapy (IT), alone and in combination with traditional treatments, has emerged as a reckoning force to combat the spread of BrM and shrink tumor burden. This review compiles recent reports describing the potential role of IT in the treatment of BrM in various cancers. It also examines the impact of the tumor microenvironment of BrM on regulating the spread of cancer and the role IT can play in mitigating that spread. Lastly, this review also focuses on the future of IT and new clinical trials pushing the boundaries of IT in BrM.
MeSH Headings
Humans, Brain Neoplasms, Immunotherapy, Tumor Microenvironment
ISSN
1476-4598
DOI Link
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Ahmad, Aatiya; Khan, Parvez; Rehman, Asad Ur; Batra, Surinder K.; and Nasser, Mohd W., "Immunotherapy: An Emerging Modality to Checkmate Brain Metastasis" (2023). Journal Articles: Biochemistry & Molecular Biology. 162.
https://digitalcommons.unmc.edu/com_bio_articles/162