Advances in Cancer Biology - Metastasis
Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.
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Benjamin, Mercilena; Malakar, Pushkar; Sinha, Rohit Anthony; Nasser, Mohd Wasim; Batra, Surinder K.; Siddiqui, Jawed A.; and Chakravarti, Bandana, "Molecular Signaling Network and Therapeutic Developments in Breast Cancer Brain Metastasis" (2023). Journal Articles: Biochemistry & Molecular Biology. 159.